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Anti-HHIP/ HIP functional antibody
Anti-HHIP/ HIP functional antibody for cell culture, ELISA & in-vivo assay
Go to HHIP/HHIP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0261-Ab-1/ GM-Tg-hg-SE0261-Ab-2 | Anti-Human HHIP monoclonal antibody | Human |
| GM-Tg-rg-SE0261-Ab-1/ GM-Tg-rg-SE0261-Ab-2 | Anti-Rat HHIP monoclonal antibody | Rat |
| GM-Tg-mg-SE0261-Ab-1/ GM-Tg-mg-SE0261-Ab-2 | Anti-Mouse HHIP monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0261-Ab-1/ GM-Tg-cynog-SE0261-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HHIP monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0261-Ab-1/ GM-Tg-felg-SE0261-Ab-2 | Anti-Feline HHIP monoclonal antibody | Feline |
| GM-Tg-cang-SE0261-Ab-1/ GM-Tg-cang-SE0261-Ab-2 | Anti-Canine HHIP monoclonal antibody | Canine |
| GM-Tg-bovg-SE0261-Ab-1/ GM-Tg-bovg-SE0261-Ab-2 | Anti-Bovine HHIP monoclonal antibody | Bovine |
| GM-Tg-equg-SE0261-Ab-1/ GM-Tg-equg-SE0261-Ab-2 | Anti-Equine HHIP monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0261-Ab-1/ GM-Tg-hg-SE0261-Ab-2; GM-Tg-rg-SE0261-Ab-1/ GM-Tg-rg-SE0261-Ab-2; GM-Tg-mg-SE0261-Ab-1/ GM-Tg-mg-SE0261-Ab-2; GM-Tg-cynog-SE0261-Ab-1/ GM-Tg-cynog-SE0261-Ab-2; GM-Tg-felg-SE0261-Ab-1/ GM-Tg-felg-SE0261-Ab-2; GM-Tg-cang-SE0261-Ab-1/ GM-Tg-cang-SE0261-Ab-2; GM-Tg-bovg-SE0261-Ab-1/ GM-Tg-bovg-SE0261-Ab-2; GM-Tg-equg-SE0261-Ab-1/ GM-Tg-equg-SE0261-Ab-2 |
| Products Name | Anti-HHIP monoclonal antibody |
| Format | mab |
| Target Name | HHIP |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HHIP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0261-Ag-1 | Recombinant multi-species HHIP/ HIP protein |
Target information
| Target ID | GM-SE0261 |
| Target Name | HHIP |
| Gene ID | 64399,15245,291936,701205,100855424,101087058,540830,100062868 |
| Gene Symbol and Synonyms | HHIP,Hhip1,HIP,RGD1564108 |
| Uniprot Accession | Q96QV1 |
| Uniprot Entry Name | HHIP_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000164161 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: HHIP, gene name: HHIP, also named as HIP. This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.[provided by RefSeq, Feb 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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