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Anti-DHI1L/ HSD11B1L/ 11-DH3 functional antibody
Anti-DHI1L/ HSD11B1L/ 11-DH3 functional antibody for cell culture, ELISA & in-vivo assay
Go to HSD11B1L/HSD11B1L products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0269-Ab-1/ GM-Tg-hg-SE0269-Ab-2 | Anti-Human HSD11B1L monoclonal antibody | Human |
| GM-Tg-rg-SE0269-Ab-1/ GM-Tg-rg-SE0269-Ab-2 | Anti-Rat HSD11B1L monoclonal antibody | Rat |
| GM-Tg-mg-SE0269-Ab-1/ GM-Tg-mg-SE0269-Ab-2 | Anti-Mouse HSD11B1L monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0269-Ab-1/ GM-Tg-cynog-SE0269-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HSD11B1L monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0269-Ab-1/ GM-Tg-felg-SE0269-Ab-2 | Anti-Feline HSD11B1L monoclonal antibody | Feline |
| GM-Tg-cang-SE0269-Ab-1/ GM-Tg-cang-SE0269-Ab-2 | Anti-Canine HSD11B1L monoclonal antibody | Canine |
| GM-Tg-bovg-SE0269-Ab-1/ GM-Tg-bovg-SE0269-Ab-2 | Anti-Bovine HSD11B1L monoclonal antibody | Bovine |
| GM-Tg-equg-SE0269-Ab-1/ GM-Tg-equg-SE0269-Ab-2 | Anti-Equine HSD11B1L monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0269-Ab-1/ GM-Tg-hg-SE0269-Ab-2; GM-Tg-rg-SE0269-Ab-1/ GM-Tg-rg-SE0269-Ab-2; GM-Tg-mg-SE0269-Ab-1/ GM-Tg-mg-SE0269-Ab-2; GM-Tg-cynog-SE0269-Ab-1/ GM-Tg-cynog-SE0269-Ab-2; GM-Tg-felg-SE0269-Ab-1/ GM-Tg-felg-SE0269-Ab-2; GM-Tg-cang-SE0269-Ab-1/ GM-Tg-cang-SE0269-Ab-2; GM-Tg-bovg-SE0269-Ab-1/ GM-Tg-bovg-SE0269-Ab-2; GM-Tg-equg-SE0269-Ab-1/ GM-Tg-equg-SE0269-Ab-2 |
| Products Name | Anti-HSD11B1L monoclonal antibody |
| Format | mab |
| Target Name | HSD11B1L |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HSD11B1L benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0269-Ag-1 | Recombinant multi-species DHI1L/ HSD11B1L/ 11-DH3 protein |
Target information
| Target ID | GM-SE0269 |
| Target Name | HSD11B1L |
| Gene ID | 374875,696612,485027,101092746,404546,100147231 |
| Gene Symbol and Synonyms | 11-beta-HSD3,11-DH3,HSD11B1L,HSD1L,HSD3,SCDR10,SCDR10B,SDR26C2 |
| Uniprot Accession | Q7Z5J1,Q6Q7D1 |
| Uniprot Entry Name | DHI1L_HUMAN,DHI1L_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000167733 |
| Target Classification | N/A |
The target: HSD11B1L, gene name: HSD11B1L, also named as 11-DH3, 11-beta-HSD3, HSD3, SCDR10, SCDR10B, SDR26C2. This gene is a member of the hydroxysteroid dehydrogenase family. The encoded protein is similar to an enzyme that catalyzes the interconversion of inactive to active glucocorticoids (e.g. cortisone). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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