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Anti-K0100/ KIAA0100/ BCOX functional antibody
Anti-K0100/ KIAA0100/ BCOX functional antibody for cell culture, ELISA & in-vivo assay
Go to KIAA0100/KIAA0100 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0294-Ab-1/ GM-Tg-hg-SE0294-Ab-2 | Anti-Human KIAA0100 monoclonal antibody | Human |
| GM-Tg-rg-SE0294-Ab-1/ GM-Tg-rg-SE0294-Ab-2 | Anti-Rat KIAA0100 monoclonal antibody | Rat |
| GM-Tg-mg-SE0294-Ab-1/ GM-Tg-mg-SE0294-Ab-2 | Anti-Mouse KIAA0100 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0294-Ab-1/ GM-Tg-cynog-SE0294-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KIAA0100 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0294-Ab-1/ GM-Tg-felg-SE0294-Ab-2 | Anti-Feline KIAA0100 monoclonal antibody | Feline |
| GM-Tg-cang-SE0294-Ab-1/ GM-Tg-cang-SE0294-Ab-2 | Anti-Canine KIAA0100 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0294-Ab-1/ GM-Tg-bovg-SE0294-Ab-2 | Anti-Bovine KIAA0100 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0294-Ab-1/ GM-Tg-equg-SE0294-Ab-2 | Anti-Equine KIAA0100 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0294-Ab-1/ GM-Tg-hg-SE0294-Ab-2; GM-Tg-rg-SE0294-Ab-1/ GM-Tg-rg-SE0294-Ab-2; GM-Tg-mg-SE0294-Ab-1/ GM-Tg-mg-SE0294-Ab-2; GM-Tg-cynog-SE0294-Ab-1/ GM-Tg-cynog-SE0294-Ab-2; GM-Tg-felg-SE0294-Ab-1/ GM-Tg-felg-SE0294-Ab-2; GM-Tg-cang-SE0294-Ab-1/ GM-Tg-cang-SE0294-Ab-2; GM-Tg-bovg-SE0294-Ab-1/ GM-Tg-bovg-SE0294-Ab-2; GM-Tg-equg-SE0294-Ab-1/ GM-Tg-equg-SE0294-Ab-2 |
| Products Name | Anti-KIAA0100 monoclonal antibody |
| Format | mab |
| Target Name | KIAA0100 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-KIAA0100 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0294-Ag-1 | Recombinant multi-species K0100/ KIAA0100/ BCOX protein |
Target information
| Target ID | GM-SE0294 |
| Target Name | KIAA0100 |
| Gene ID | 9703,72503,303280,709307,480625,101085330,517133,100072067 |
| Gene Symbol and Synonyms | 2610507B11Rik,BCOX,BCOX1,BLTP2,CT101,D11Bhm178e,D11Bhm179e,E1,FMP27,Hob,KIAA0100,mKIAA0100,RGD1307929 |
| Uniprot Accession | Q14667 |
| Uniprot Entry Name | K0100_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000007202 |
| Target Classification | N/A |
The target: KIAA0100, gene name: KIAA0100, also named as BCOX, BCOX1, CT101, FMP27. This gene was initially characterized in human as having high expression levels in breast carcinomas and breast cancer cell lines. This gene also has increased expression in prostrate cancer cells relative to normal prostrate tissues. Expression of this gene is negatively regulated by direct binding of the microRNA miR-195 to its 3' UTR. miR-195 has been shown to modulate the invasiveness of prostrate cancer cells and xenograft metastases by downgrading expression of this gene. In mouse, the protein encoded by this gene was identified as an antigen on acute monocytic leukemia cells. In human, alternative splicing results in multiple transcript variants encoding distinct isoforms; some of these isoforms are predicted to contain an RNA pol II promoter FMP27 protein domain and a Golgi-body-localization APT1 domain. [provided by RefSeq, Apr 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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