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Anti-LAMA2/ LAMM/ MDC1A functional antibody
Anti-LAMA2/ LAMM/ MDC1A functional antibody for cell culture, ELISA & in-vivo assay
Go to LAMA2/LAMA2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0296-Ab-1/ GM-Tg-hg-SE0296-Ab-2 | Anti-Human LAMA2 monoclonal antibody | Human |
| GM-Tg-rg-SE0296-Ab-1/ GM-Tg-rg-SE0296-Ab-2 | Anti-Rat LAMA2 monoclonal antibody | Rat |
| GM-Tg-mg-SE0296-Ab-1/ GM-Tg-mg-SE0296-Ab-2 | Anti-Mouse LAMA2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0296-Ab-1/ GM-Tg-cynog-SE0296-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LAMA2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0296-Ab-1/ GM-Tg-felg-SE0296-Ab-2 | Anti-Feline LAMA2 monoclonal antibody | Feline |
| GM-Tg-cang-SE0296-Ab-1/ GM-Tg-cang-SE0296-Ab-2 | Anti-Canine LAMA2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0296-Ab-1/ GM-Tg-bovg-SE0296-Ab-2 | Anti-Bovine LAMA2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0296-Ab-1/ GM-Tg-equg-SE0296-Ab-2 | Anti-Equine LAMA2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0296-Ab-1/ GM-Tg-hg-SE0296-Ab-2; GM-Tg-rg-SE0296-Ab-1/ GM-Tg-rg-SE0296-Ab-2; GM-Tg-mg-SE0296-Ab-1/ GM-Tg-mg-SE0296-Ab-2; GM-Tg-cynog-SE0296-Ab-1/ GM-Tg-cynog-SE0296-Ab-2; GM-Tg-felg-SE0296-Ab-1/ GM-Tg-felg-SE0296-Ab-2; GM-Tg-cang-SE0296-Ab-1/ GM-Tg-cang-SE0296-Ab-2; GM-Tg-bovg-SE0296-Ab-1/ GM-Tg-bovg-SE0296-Ab-2; GM-Tg-equg-SE0296-Ab-1/ GM-Tg-equg-SE0296-Ab-2 |
| Products Name | Anti-LAMA2 monoclonal antibody |
| Format | mab |
| Target Name | LAMA2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LAMA2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0296-Ag-1 | Recombinant multi-species LAMA2/ LAMM/ MDC1A protein |
Target information
| Target ID | GM-SE0296 |
| Target Name | LAMA2 |
| Gene ID | 3908,16773,309368,715394,100683420,101092612,100138434,100073067 |
| Gene Symbol and Synonyms | 5830440B04,dy,LAMA2,LAMM,MDC1A,mer,merosin,mKIAA4087 |
| Uniprot Accession | P24043 |
| Uniprot Entry Name | LAMA2_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000196569 |
| Target Classification | N/A |
The target: LAMA2, gene name: LAMA2, also named as LAMM, MDC1A. Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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