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Anti-LAMA3/ BM600/ E170 functional antibody
Anti-LAMA3/ BM600/ E170 functional antibody for cell culture, ELISA & in-vivo assay
Go to LAMA3/LAMA3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0297-Ab-1/ GM-Tg-hg-SE0297-Ab-2 | Anti-Human LAMA3 monoclonal antibody | Human |
| GM-Tg-rg-SE0297-Ab-1/ GM-Tg-rg-SE0297-Ab-2 | Anti-Rat LAMA3 monoclonal antibody | Rat |
| GM-Tg-mg-SE0297-Ab-1/ GM-Tg-mg-SE0297-Ab-2 | Anti-Mouse LAMA3 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0297-Ab-1/ GM-Tg-cynog-SE0297-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LAMA3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0297-Ab-1/ GM-Tg-felg-SE0297-Ab-2 | Anti-Feline LAMA3 monoclonal antibody | Feline |
| GM-Tg-cang-SE0297-Ab-1/ GM-Tg-cang-SE0297-Ab-2 | Anti-Canine LAMA3 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0297-Ab-1/ GM-Tg-bovg-SE0297-Ab-2 | Anti-Bovine LAMA3 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0297-Ab-1/ GM-Tg-equg-SE0297-Ab-2 | Anti-Equine LAMA3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0297-Ab-1/ GM-Tg-hg-SE0297-Ab-2; GM-Tg-rg-SE0297-Ab-1/ GM-Tg-rg-SE0297-Ab-2; GM-Tg-mg-SE0297-Ab-1/ GM-Tg-mg-SE0297-Ab-2; GM-Tg-cynog-SE0297-Ab-1/ GM-Tg-cynog-SE0297-Ab-2; GM-Tg-felg-SE0297-Ab-1/ GM-Tg-felg-SE0297-Ab-2; GM-Tg-cang-SE0297-Ab-1/ GM-Tg-cang-SE0297-Ab-2; GM-Tg-bovg-SE0297-Ab-1/ GM-Tg-bovg-SE0297-Ab-2; GM-Tg-equg-SE0297-Ab-1/ GM-Tg-equg-SE0297-Ab-2 |
| Products Name | Anti-LAMA3 monoclonal antibody |
| Format | mab |
| Target Name | LAMA3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LAMA3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0297-Ag-1 | Recombinant multi-species LAMA3/ BM600/ E170 protein |
Target information
| Target ID | GM-SE0297 |
| Target Name | LAMA3 |
| Gene ID | 3909,16774,307582,701313,480173,101100161,100336873,791238 |
| Gene Symbol and Synonyms | BM600,E170,JEB2A,JEB2B,JEB2C,LAMA3,Lama3B,LAMNA,LOCS,[a]3B |
| Uniprot Accession | Q16787 |
| Uniprot Entry Name | LAMA3_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000053747 |
| Target Classification | N/A |
The target: LAMA3, gene name: LAMA3, also named as BM600, E170, LAMNA, LOCS. The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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