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Anti-LAMA5 functional antibody
Anti-LAMA5 functional antibody for cell culture, ELISA & in-vivo assay
Go to LAMA5/LAMA5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0299-Ab-1/ GM-Tg-hg-SE0299-Ab-2 | Anti-Human LAMA5 monoclonal antibody | Human |
| GM-Tg-rg-SE0299-Ab-1/ GM-Tg-rg-SE0299-Ab-2 | Anti-Rat LAMA5 monoclonal antibody | Rat |
| GM-Tg-mg-SE0299-Ab-1/ GM-Tg-mg-SE0299-Ab-2 | Anti-Mouse LAMA5 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0299-Ab-1/ GM-Tg-cynog-SE0299-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LAMA5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0299-Ab-1/ GM-Tg-felg-SE0299-Ab-2 | Anti-Feline LAMA5 monoclonal antibody | Feline |
| GM-Tg-cang-SE0299-Ab-1/ GM-Tg-cang-SE0299-Ab-2 | Anti-Canine LAMA5 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0299-Ab-1/ GM-Tg-bovg-SE0299-Ab-2 | Anti-Bovine LAMA5 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0299-Ab-1/ GM-Tg-equg-SE0299-Ab-2 | Anti-Equine LAMA5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0299-Ab-1/ GM-Tg-hg-SE0299-Ab-2; GM-Tg-rg-SE0299-Ab-1/ GM-Tg-rg-SE0299-Ab-2; GM-Tg-mg-SE0299-Ab-1/ GM-Tg-mg-SE0299-Ab-2; GM-Tg-cynog-SE0299-Ab-1/ GM-Tg-cynog-SE0299-Ab-2; GM-Tg-felg-SE0299-Ab-1/ GM-Tg-felg-SE0299-Ab-2; GM-Tg-cang-SE0299-Ab-1/ GM-Tg-cang-SE0299-Ab-2; GM-Tg-bovg-SE0299-Ab-1/ GM-Tg-bovg-SE0299-Ab-2; GM-Tg-equg-SE0299-Ab-1/ GM-Tg-equg-SE0299-Ab-2 |
| Products Name | Anti-LAMA5 monoclonal antibody |
| Format | mab |
| Target Name | LAMA5 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LAMA5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0299-Ag-1 | Recombinant multi-species LAMA5 protein |
Target information
| Target ID | GM-SE0299 |
| Target Name | LAMA5 |
| Gene ID | 3911,16776,140433,100430603,442954,101083923,506751,100058057 |
| Gene Symbol and Synonyms | BBDS2,LAMA5,laminin-511,mKIAA0533,NPHS26,[a]5 |
| Uniprot Accession | O15230 |
| Uniprot Entry Name | LAMA5_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Ovary Cancer |
| Gene Ensembl | ENSG00000130702 |
| Target Classification | N/A |
The target: LAMA5, gene name: LAMA5, also named as . This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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