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Anti-CNMD/ BRICD3/ CHM-I functional antibody
Anti-CNMD/ BRICD3/ CHM-I functional antibody for cell culture, ELISA & in-vivo assay
Go to CNMD/CNMD products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0305-Ab-1/ GM-Tg-hg-SE0305-Ab-2 | Anti-Human CNMD monoclonal antibody | Human |
| GM-Tg-rg-SE0305-Ab-1/ GM-Tg-rg-SE0305-Ab-2 | Anti-Rat CNMD monoclonal antibody | Rat |
| GM-Tg-mg-SE0305-Ab-1/ GM-Tg-mg-SE0305-Ab-2 | Anti-Mouse CNMD monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0305-Ab-1/ GM-Tg-cynog-SE0305-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CNMD monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0305-Ab-1/ GM-Tg-felg-SE0305-Ab-2 | Anti-Feline CNMD monoclonal antibody | Feline |
| GM-Tg-cang-SE0305-Ab-1/ GM-Tg-cang-SE0305-Ab-2 | Anti-Canine CNMD monoclonal antibody | Canine |
| GM-Tg-bovg-SE0305-Ab-1/ GM-Tg-bovg-SE0305-Ab-2 | Anti-Bovine CNMD monoclonal antibody | Bovine |
| GM-Tg-equg-SE0305-Ab-1/ GM-Tg-equg-SE0305-Ab-2 | Anti-Equine CNMD monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0305-Ab-1/ GM-Tg-hg-SE0305-Ab-2; GM-Tg-rg-SE0305-Ab-1/ GM-Tg-rg-SE0305-Ab-2; GM-Tg-mg-SE0305-Ab-1/ GM-Tg-mg-SE0305-Ab-2; GM-Tg-cynog-SE0305-Ab-1/ GM-Tg-cynog-SE0305-Ab-2; GM-Tg-felg-SE0305-Ab-1/ GM-Tg-felg-SE0305-Ab-2; GM-Tg-cang-SE0305-Ab-1/ GM-Tg-cang-SE0305-Ab-2; GM-Tg-bovg-SE0305-Ab-1/ GM-Tg-bovg-SE0305-Ab-2; GM-Tg-equg-SE0305-Ab-1/ GM-Tg-equg-SE0305-Ab-2 |
| Products Name | Anti-CNMD monoclonal antibody |
| Format | mab |
| Target Name | CNMD |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CNMD benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0305-Ag-1 | Recombinant multi-species CNMD/ BRICD3/ CHM-I protein |
Target information
| Target ID | GM-SE0305 |
| Target Name | CNMD |
| Gene ID | 11061,16840,81512,694189,609613,101091335,281683,100051618 |
| Gene Symbol and Synonyms | BRICD3,Chm-1,CHM-I,CHM1,Chmd,CNMD,LECT1,MYETS1 |
| Uniprot Accession | O75829,O70367,P17404 |
| Uniprot Entry Name | CNMD_HUMAN,CNMD_RAT,CNMD_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000136110 |
| Target Classification | N/A |
The target: CNMD, gene name: CNMD, also named as BRICD3, CHM-I, CHM1, LECT1, MYETS1. This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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