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Anti-LGI2/ LGIL2 functional antibody
Anti-LGI2/ LGIL2 functional antibody for cell culture, ELISA & in-vivo assay
Go to LGI2/LGI2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0309-Ab-1/ GM-Tg-hg-SE0309-Ab-2 | Anti-Human LGI2 monoclonal antibody | Human |
| GM-Tg-rg-SE0309-Ab-1/ GM-Tg-rg-SE0309-Ab-2 | Anti-Rat LGI2 monoclonal antibody | Rat |
| GM-Tg-mg-SE0309-Ab-1/ GM-Tg-mg-SE0309-Ab-2 | Anti-Mouse LGI2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0309-Ab-1/ GM-Tg-cynog-SE0309-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LGI2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0309-Ab-1/ GM-Tg-felg-SE0309-Ab-2 | Anti-Feline LGI2 monoclonal antibody | Feline |
| GM-Tg-cang-SE0309-Ab-1/ GM-Tg-cang-SE0309-Ab-2 | Anti-Canine LGI2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0309-Ab-1/ GM-Tg-bovg-SE0309-Ab-2 | Anti-Bovine LGI2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0309-Ab-1/ GM-Tg-equg-SE0309-Ab-2 | Anti-Equine LGI2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0309-Ab-1/ GM-Tg-hg-SE0309-Ab-2; GM-Tg-rg-SE0309-Ab-1/ GM-Tg-rg-SE0309-Ab-2; GM-Tg-mg-SE0309-Ab-1/ GM-Tg-mg-SE0309-Ab-2; GM-Tg-cynog-SE0309-Ab-1/ GM-Tg-cynog-SE0309-Ab-2; GM-Tg-felg-SE0309-Ab-1/ GM-Tg-felg-SE0309-Ab-2; GM-Tg-cang-SE0309-Ab-1/ GM-Tg-cang-SE0309-Ab-2; GM-Tg-bovg-SE0309-Ab-1/ GM-Tg-bovg-SE0309-Ab-2; GM-Tg-equg-SE0309-Ab-1/ GM-Tg-equg-SE0309-Ab-2 |
| Products Name | Anti-LGI2 monoclonal antibody |
| Format | mab |
| Target Name | LGI2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LGI2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0309-Ag-1 | Recombinant multi-species LGI2/ LGIL2 protein |
Target information
| Target ID | GM-SE0309 |
| Target Name | LGI2 |
| Gene ID | 55203,246316,305417,693308,488853,101082903,541046,100067566 |
| Gene Symbol and Synonyms | LGI2,LGIL2,mKIAA1916 |
| Uniprot Accession | Q8N0V4 |
| Uniprot Entry Name | LGI2_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000153012 |
| Target Classification | N/A |
The target: LGI2, gene name: LGI2, also named as LGIL2. Predicted to be involved in inhibitory synapse assembly. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
