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Anti-LRC3B/ LRRC3B/ LRP15 functional antibody
Anti-LRC3B/ LRRC3B/ LRP15 functional antibody for cell culture, ELISA & in-vivo assay
Go to LRRC3B/LRRC3B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0319-Ab-1/ GM-Tg-hg-SE0319-Ab-2 | Anti-Human LRRC3B monoclonal antibody | Human |
| GM-Tg-rg-SE0319-Ab-1/ GM-Tg-rg-SE0319-Ab-2 | Anti-Rat LRRC3B monoclonal antibody | Rat |
| GM-Tg-mg-SE0319-Ab-1/ GM-Tg-mg-SE0319-Ab-2 | Anti-Mouse LRRC3B monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0319-Ab-1/ GM-Tg-cynog-SE0319-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LRRC3B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0319-Ab-1/ GM-Tg-felg-SE0319-Ab-2 | Anti-Feline LRRC3B monoclonal antibody | Feline |
| GM-Tg-cang-SE0319-Ab-1/ GM-Tg-cang-SE0319-Ab-2 | Anti-Canine LRRC3B monoclonal antibody | Canine |
| GM-Tg-bovg-SE0319-Ab-1/ GM-Tg-bovg-SE0319-Ab-2 | Anti-Bovine LRRC3B monoclonal antibody | Bovine |
| GM-Tg-equg-SE0319-Ab-1/ GM-Tg-equg-SE0319-Ab-2 | Anti-Equine LRRC3B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0319-Ab-1/ GM-Tg-hg-SE0319-Ab-2; GM-Tg-rg-SE0319-Ab-1/ GM-Tg-rg-SE0319-Ab-2; GM-Tg-mg-SE0319-Ab-1/ GM-Tg-mg-SE0319-Ab-2; GM-Tg-cynog-SE0319-Ab-1/ GM-Tg-cynog-SE0319-Ab-2; GM-Tg-felg-SE0319-Ab-1/ GM-Tg-felg-SE0319-Ab-2; GM-Tg-cang-SE0319-Ab-1/ GM-Tg-cang-SE0319-Ab-2; GM-Tg-bovg-SE0319-Ab-1/ GM-Tg-bovg-SE0319-Ab-2; GM-Tg-equg-SE0319-Ab-1/ GM-Tg-equg-SE0319-Ab-2 |
| Products Name | Anti-LRRC3B monoclonal antibody |
| Format | mab |
| Target Name | LRRC3B |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LRRC3B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0319-Ag-1 | Recombinant multi-species LRC3B/ LRRC3B/ LRP15 protein |
Target information
| Target ID | GM-SE0319 |
| Target Name | LRRC3B |
| Gene ID | 116135,218763,305705,701323,485639,101086594,783571,100051404 |
| Gene Symbol and Synonyms | LRP15,LRRC3B,RGD1311897 |
| Uniprot Accession | Q96PB8,A6H789 |
| Uniprot Entry Name | LRC3B_HUMAN,LRC3B_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000179796 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: LRRC3B, gene name: LRRC3B, also named as LRP15. The protein encoded by this gene is a tumor suppressor, with lowered expression levels found in gastric, renal, colorectal, lung, and breast cancer tissues. The promoter of this gene is frequently hypermethylated in these cancer tissues, although the hypermethylation does not appear to be the cause of the reduced expression of this gene. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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