Anti-LRRT3/ LRR™3 functional antibody

Anti-LRRT3/ LRR™3 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to LRR™3/LRR™3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0325-Ab-1/ GM-Tg-hg-SE0325-Ab-2Anti-Human LRR™3 monoclonal antibodyHuman
GM-Tg-rg-SE0325-Ab-1/ GM-Tg-rg-SE0325-Ab-2Anti-Rat LRR™3 monoclonal antibodyRat
GM-Tg-mg-SE0325-Ab-1/ GM-Tg-mg-SE0325-Ab-2Anti-Mouse LRR™3 monoclonal antibodyMouse
GM-Tg-cynog-SE0325-Ab-1/ GM-Tg-cynog-SE0325-Ab-2Anti-Cynomolgus/ Rhesus macaque LRR™3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0325-Ab-1/ GM-Tg-felg-SE0325-Ab-2Anti-Feline LRR™3 monoclonal antibodyFeline
GM-Tg-cang-SE0325-Ab-1/ GM-Tg-cang-SE0325-Ab-2Anti-Canine LRR™3 monoclonal antibodyCanine
GM-Tg-bovg-SE0325-Ab-1/ GM-Tg-bovg-SE0325-Ab-2Anti-Bovine LRR™3 monoclonal antibodyBovine
GM-Tg-equg-SE0325-Ab-1/ GM-Tg-equg-SE0325-Ab-2Anti-Equine LRR™3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0325-Ab-1/ GM-Tg-hg-SE0325-Ab-2; GM-Tg-rg-SE0325-Ab-1/ GM-Tg-rg-SE0325-Ab-2;
GM-Tg-mg-SE0325-Ab-1/ GM-Tg-mg-SE0325-Ab-2; GM-Tg-cynog-SE0325-Ab-1/ GM-Tg-cynog-SE0325-Ab-2;
GM-Tg-felg-SE0325-Ab-1/ GM-Tg-felg-SE0325-Ab-2; GM-Tg-cang-SE0325-Ab-1/ GM-Tg-cang-SE0325-Ab-2;
GM-Tg-bovg-SE0325-Ab-1/ GM-Tg-bovg-SE0325-Ab-2; GM-Tg-equg-SE0325-Ab-1/ GM-Tg-equg-SE0325-Ab-2
Products NameAnti-LRR™3 monoclonal antibody
Formatmab
Target NameLRR™3
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-LRR™3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0325-Ag-1Recombinant multi-species LRRT3/ LRR™3 protein


    Target information

    Target IDGM-SE0325
    Target NameLRR™3
    Gene ID347731,216028,294380,696536,489009,101086600,538148,100062943
    Gene Symbol and Synonyms9630044H04Rik,LRR™3
    Uniprot AccessionQ86VH5,D3ZAL8
    Uniprot Entry NameLRRT3_HUMAN,LRRT3_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000198739
    Target ClassificationN/A

    The target: LRR™3, gene name: LRR™3, also named as . Involved in presynapse assembly. Acts upstream of or within positive regulation of amyloid-beta formation. Is active in glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.