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Anti-MEP1B functional antibody
Anti-MEP1B functional antibody for cell culture, ELISA & in-vivo assay
Go to MEP1B/MEP1B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0337-Ab-1/ GM-Tg-hg-SE0337-Ab-2 | Anti-Human MEP1B monoclonal antibody | Human |
| GM-Tg-rg-SE0337-Ab-1/ GM-Tg-rg-SE0337-Ab-2 | Anti-Rat MEP1B monoclonal antibody | Rat |
| GM-Tg-mg-SE0337-Ab-1/ GM-Tg-mg-SE0337-Ab-2 | Anti-Mouse MEP1B monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0337-Ab-1/ GM-Tg-cynog-SE0337-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MEP1B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0337-Ab-1/ GM-Tg-felg-SE0337-Ab-2 | Anti-Feline MEP1B monoclonal antibody | Feline |
| GM-Tg-cang-SE0337-Ab-1/ GM-Tg-cang-SE0337-Ab-2 | Anti-Canine MEP1B monoclonal antibody | Canine |
| GM-Tg-bovg-SE0337-Ab-1/ GM-Tg-bovg-SE0337-Ab-2 | Anti-Bovine MEP1B monoclonal antibody | Bovine |
| GM-Tg-equg-SE0337-Ab-1/ GM-Tg-equg-SE0337-Ab-2 | Anti-Equine MEP1B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0337-Ab-1/ GM-Tg-hg-SE0337-Ab-2; GM-Tg-rg-SE0337-Ab-1/ GM-Tg-rg-SE0337-Ab-2; GM-Tg-mg-SE0337-Ab-1/ GM-Tg-mg-SE0337-Ab-2; GM-Tg-cynog-SE0337-Ab-1/ GM-Tg-cynog-SE0337-Ab-2; GM-Tg-felg-SE0337-Ab-1/ GM-Tg-felg-SE0337-Ab-2; GM-Tg-cang-SE0337-Ab-1/ GM-Tg-cang-SE0337-Ab-2; GM-Tg-bovg-SE0337-Ab-1/ GM-Tg-bovg-SE0337-Ab-2; GM-Tg-equg-SE0337-Ab-1/ GM-Tg-equg-SE0337-Ab-2 |
| Products Name | Anti-MEP1B monoclonal antibody |
| Format | mab |
| Target Name | MEP1B |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MEP1B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0337-Ag-1 | Recombinant multi-species MEP1B protein |
Target information
| Target ID | GM-SE0337 |
| Target Name | MEP1B |
| Gene ID | 4225,17288,25727,707036,490497,101089149,540701,100052389 |
| Gene Symbol and Synonyms | Mep-1b,MEP1B |
| Uniprot Accession | Q16820,P28826 |
| Uniprot Entry Name | MEP1B_HUMAN,MEP1B_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000141434 |
| Target Classification | N/A |
The target: MEP1B, gene name: MEP1B, also named as . Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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