Anti-NF2L3/ NFE2L3/ NRF3 functional antibody

Anti-NF2L3/ NFE2L3/ NRF3 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to NFE2L3/NFE2L3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0366-Ab-1/ GM-Tg-hg-SE0366-Ab-2Anti-Human NFE2L3 monoclonal antibodyHuman
GM-Tg-rg-SE0366-Ab-1/ GM-Tg-rg-SE0366-Ab-2Anti-Rat NFE2L3 monoclonal antibodyRat
GM-Tg-mg-SE0366-Ab-1/ GM-Tg-mg-SE0366-Ab-2Anti-Mouse NFE2L3 monoclonal antibodyMouse
GM-Tg-cynog-SE0366-Ab-1/ GM-Tg-cynog-SE0366-Ab-2Anti-Cynomolgus/ Rhesus macaque NFE2L3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0366-Ab-1/ GM-Tg-felg-SE0366-Ab-2Anti-Feline NFE2L3 monoclonal antibodyFeline
GM-Tg-cang-SE0366-Ab-1/ GM-Tg-cang-SE0366-Ab-2Anti-Canine NFE2L3 monoclonal antibodyCanine
GM-Tg-bovg-SE0366-Ab-1/ GM-Tg-bovg-SE0366-Ab-2Anti-Bovine NFE2L3 monoclonal antibodyBovine
GM-Tg-equg-SE0366-Ab-1/ GM-Tg-equg-SE0366-Ab-2Anti-Equine NFE2L3 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0366-Ab-1/ GM-Tg-hg-SE0366-Ab-2; GM-Tg-rg-SE0366-Ab-1/ GM-Tg-rg-SE0366-Ab-2;
GM-Tg-mg-SE0366-Ab-1/ GM-Tg-mg-SE0366-Ab-2; GM-Tg-cynog-SE0366-Ab-1/ GM-Tg-cynog-SE0366-Ab-2;
GM-Tg-felg-SE0366-Ab-1/ GM-Tg-felg-SE0366-Ab-2; GM-Tg-cang-SE0366-Ab-1/ GM-Tg-cang-SE0366-Ab-2;
GM-Tg-bovg-SE0366-Ab-1/ GM-Tg-bovg-SE0366-Ab-2; GM-Tg-equg-SE0366-Ab-1/ GM-Tg-equg-SE0366-Ab-2
Products NameAnti-NFE2L3 monoclonal antibody
Formatmab
Target NameNFE2L3
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NFE2L3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0366-Ag-1Recombinant multi-species NF2L3/ NFE2L3/ NRF3 protein
    ORF Viral VectorvGMLP003931human NFE2L3 Lentivirus particle
    ORF Viral VectorpGMLP003931human NFE2L3 Lentivirus plasmid
    ORF Viral VectorpGMLPm003003mouse Nfe2l3 Lentivirus plasmid
    ORF Viral VectorvGMLPm003003mouse Nfe2l3 Lentivirus particle


    Target information

    Target IDGM-SE0366
    Target NameNFE2L3
    Gene ID9603,18025,312331,702171,482364,101082479,510807,100068518
    Gene Symbol and SynonymsNFE2L3,NRF3
    Uniprot AccessionQ9Y4A8
    Uniprot Entry NameNF2L3_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000050344
    Target ClassificationN/A

    The target: NFE2L3, gene name: NFE2L3, also named as NRF3. This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [provided by RefSeq, Mar 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.