Anti-NMU functional antibody

Anti-NMU functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to NMU/NMU products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0371-Ab-1/ GM-Tg-hg-SE0371-Ab-2Anti-Human NMU monoclonal antibodyHuman
GM-Tg-rg-SE0371-Ab-1/ GM-Tg-rg-SE0371-Ab-2Anti-Rat NMU monoclonal antibodyRat
GM-Tg-mg-SE0371-Ab-1/ GM-Tg-mg-SE0371-Ab-2Anti-Mouse NMU monoclonal antibodyMouse
GM-Tg-cynog-SE0371-Ab-1/ GM-Tg-cynog-SE0371-Ab-2Anti-Cynomolgus/ Rhesus macaque NMU monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0371-Ab-1/ GM-Tg-felg-SE0371-Ab-2Anti-Feline NMU monoclonal antibodyFeline
GM-Tg-cang-SE0371-Ab-1/ GM-Tg-cang-SE0371-Ab-2Anti-Canine NMU monoclonal antibodyCanine
GM-Tg-bovg-SE0371-Ab-1/ GM-Tg-bovg-SE0371-Ab-2Anti-Bovine NMU monoclonal antibodyBovine
GM-Tg-equg-SE0371-Ab-1/ GM-Tg-equg-SE0371-Ab-2Anti-Equine NMU monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0371-Ab-1/ GM-Tg-hg-SE0371-Ab-2; GM-Tg-rg-SE0371-Ab-1/ GM-Tg-rg-SE0371-Ab-2;
GM-Tg-mg-SE0371-Ab-1/ GM-Tg-mg-SE0371-Ab-2; GM-Tg-cynog-SE0371-Ab-1/ GM-Tg-cynog-SE0371-Ab-2;
GM-Tg-felg-SE0371-Ab-1/ GM-Tg-felg-SE0371-Ab-2; GM-Tg-cang-SE0371-Ab-1/ GM-Tg-cang-SE0371-Ab-2;
GM-Tg-bovg-SE0371-Ab-1/ GM-Tg-bovg-SE0371-Ab-2; GM-Tg-equg-SE0371-Ab-1/ GM-Tg-equg-SE0371-Ab-2
Products NameAnti-NMU monoclonal antibody
Formatmab
Target NameNMU
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NMU benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0371-Ag-1Recombinant multi-species NMU protein


    Target information

    Target IDGM-SE0371
    Target NameNMU
    Gene ID10874,56183,63887,697171,119874456,102899886,782109,102148328
    Gene Symbol and SynonymsNMU
    Uniprot AccessionP48645,P12760
    Uniprot Entry NameNMU_HUMAN,NMU_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseBreast Cancer, Ovary Cancer
    Gene EnsemblENSG00000109255
    Target ClassificationN/A

    The target: NMU, gene name: NMU, also named as . This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.