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Anti-NYX/ CLRP/ CSNB1 functional antibody
Anti-NYX/ CLRP/ CSNB1 functional antibody for cell culture, ELISA & in-vivo assay
Go to NYX/NYX products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0382-Ab-1/ GM-Tg-hg-SE0382-Ab-2 | Anti-Human NYX monoclonal antibody | Human |
| GM-Tg-rg-SE0382-Ab-1/ GM-Tg-rg-SE0382-Ab-2 | Anti-Rat NYX monoclonal antibody | Rat |
| GM-Tg-mg-SE0382-Ab-1/ GM-Tg-mg-SE0382-Ab-2 | Anti-Mouse NYX monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0382-Ab-1/ GM-Tg-cynog-SE0382-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NYX monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0382-Ab-1/ GM-Tg-felg-SE0382-Ab-2 | Anti-Feline NYX monoclonal antibody | Feline |
| GM-Tg-cang-SE0382-Ab-1/ GM-Tg-cang-SE0382-Ab-2 | Anti-Canine NYX monoclonal antibody | Canine |
| GM-Tg-bovg-SE0382-Ab-1/ GM-Tg-bovg-SE0382-Ab-2 | Anti-Bovine NYX monoclonal antibody | Bovine |
| GM-Tg-equg-SE0382-Ab-1/ GM-Tg-equg-SE0382-Ab-2 | Anti-Equine NYX monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0382-Ab-1/ GM-Tg-hg-SE0382-Ab-2; GM-Tg-rg-SE0382-Ab-1/ GM-Tg-rg-SE0382-Ab-2; GM-Tg-mg-SE0382-Ab-1/ GM-Tg-mg-SE0382-Ab-2; GM-Tg-cynog-SE0382-Ab-1/ GM-Tg-cynog-SE0382-Ab-2; GM-Tg-felg-SE0382-Ab-1/ GM-Tg-felg-SE0382-Ab-2; GM-Tg-cang-SE0382-Ab-1/ GM-Tg-cang-SE0382-Ab-2; GM-Tg-bovg-SE0382-Ab-1/ GM-Tg-bovg-SE0382-Ab-2; GM-Tg-equg-SE0382-Ab-1/ GM-Tg-equg-SE0382-Ab-2 |
| Products Name | Anti-NYX monoclonal antibody |
| Format | mab |
| Target Name | NYX |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NYX benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0382-Ag-1 | Recombinant multi-species NYX/ CLRP/ CSNB1 protein |
Target information
| Target ID | GM-SE0382 |
| Target Name | NYX |
| Gene ID | 60506,236690,302516,700641,111094865,101086042,101904567,111771636 |
| Gene Symbol and Synonyms | CLNP,CLRP,CSNB1,CSNB1A,CSNB4,LOC111094865,NBM1,nob,NYX,RGD1561300,SLRN |
| Uniprot Accession | Q9GZU5 |
| Uniprot Entry Name | NYX_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000188937 |
| Target Classification | N/A |
The target: NYX, gene name: NYX, also named as CLRP, CSNB1, CSNB1A, CSNB4, NBM1. The product of this gene belongs to the small leucine-rich proteoglycan (SLRP) family of proteins. Defects in this gene are the cause of congenital stationary night blindness type 1 (CSNB1), also called X-linked congenital stationary night blindness (XLCSNB). CSNB1 is a rare inherited retinal disorder characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. The role of other SLRP proteins suggests that mutations in this gene disrupt developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB. [provided by RefSeq, Oct 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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