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Anti-OTOL1/ C1QTNF15/ C1QTNF16 functional antibody
Anti-OTOL1/ C1QTNF15/ C1QTNF16 functional antibody for cell culture, ELISA & in-vivo assay
Go to OTOL1/OTOL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0391-Ab-1/ GM-Tg-hg-SE0391-Ab-2 | Anti-Human OTOL1 monoclonal antibody | Human |
| GM-Tg-rg-SE0391-Ab-1/ GM-Tg-rg-SE0391-Ab-2 | Anti-Rat OTOL1 monoclonal antibody | Rat |
| GM-Tg-mg-SE0391-Ab-1/ GM-Tg-mg-SE0391-Ab-2 | Anti-Mouse OTOL1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0391-Ab-1/ GM-Tg-cynog-SE0391-Ab-2 | Anti-Cynomolgus/ Rhesus macaque OTOL1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0391-Ab-1/ GM-Tg-felg-SE0391-Ab-2 | Anti-Feline OTOL1 monoclonal antibody | Feline |
| GM-Tg-cang-SE0391-Ab-1/ GM-Tg-cang-SE0391-Ab-2 | Anti-Canine OTOL1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0391-Ab-1/ GM-Tg-bovg-SE0391-Ab-2 | Anti-Bovine OTOL1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0391-Ab-1/ GM-Tg-equg-SE0391-Ab-2 | Anti-Equine OTOL1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0391-Ab-1/ GM-Tg-hg-SE0391-Ab-2; GM-Tg-rg-SE0391-Ab-1/ GM-Tg-rg-SE0391-Ab-2; GM-Tg-mg-SE0391-Ab-1/ GM-Tg-mg-SE0391-Ab-2; GM-Tg-cynog-SE0391-Ab-1/ GM-Tg-cynog-SE0391-Ab-2; GM-Tg-felg-SE0391-Ab-1/ GM-Tg-felg-SE0391-Ab-2; GM-Tg-cang-SE0391-Ab-1/ GM-Tg-cang-SE0391-Ab-2; GM-Tg-bovg-SE0391-Ab-1/ GM-Tg-bovg-SE0391-Ab-2; GM-Tg-equg-SE0391-Ab-1/ GM-Tg-equg-SE0391-Ab-2 |
| Products Name | Anti-OTOL1 monoclonal antibody |
| Format | mab |
| Target Name | OTOL1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-OTOL1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0391-Ag-1 | Recombinant multi-species OTOL1/ C1QTNF15/ C1QTNF16 protein |
Target information
| Target ID | GM-SE0391 |
| Target Name | OTOL1 |
| Gene ID | 131149,229389,295117,100426070,100855781,101091805,525044,100062344 |
| Gene Symbol and Synonyms | C1QTNF15,C1QTNF16,Gm414,OTOL1,RGD1562064 |
| Uniprot Accession | A6NHN0 |
| Uniprot Entry Name | OTOL1_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000182447 |
| Target Classification | N/A |
The target: OTOL1, gene name: OTOL1, also named as C1QTNF15, C1QTNF16. This gene encodes a secreted glycoprotein with a C-terminal complement Cq1-like globular domain that belongs to the C1q/tumor necrosis factor-related protein (CTRP) family. The encoded protein is expressed in the inner ear and forms a multimeric complex called the otoconia, together with cerebellin-1 and otoconin-90, as part of the otoconial membrane. It contains extensive posttranslational modifications including hydroxylated prolines and glycosylated lysines. Naturally occurring mutations in this gene are associated with abnormal otoconia formation and balance deficits resulting from vestibular dysfunction. [provided by RefSeq, Jul 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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