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Anti-PAG15/ PLA2G15/ ACS functional antibody
Anti-PAG15/ PLA2G15/ ACS functional antibody for cell culture, ELISA & in-vivo assay
Go to PLA2G15/PLA2G15 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0410-Ab-1/ GM-Tg-hg-SE0410-Ab-2 | Anti-Human PLA2G15 monoclonal antibody | Human |
| GM-Tg-rg-SE0410-Ab-1/ GM-Tg-rg-SE0410-Ab-2 | Anti-Rat PLA2G15 monoclonal antibody | Rat |
| GM-Tg-mg-SE0410-Ab-1/ GM-Tg-mg-SE0410-Ab-2 | Anti-Mouse PLA2G15 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0410-Ab-1/ GM-Tg-cynog-SE0410-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PLA2G15 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0410-Ab-1/ GM-Tg-felg-SE0410-Ab-2 | Anti-Feline PLA2G15 monoclonal antibody | Feline |
| GM-Tg-cang-SE0410-Ab-1/ GM-Tg-cang-SE0410-Ab-2 | Anti-Canine PLA2G15 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0410-Ab-1/ GM-Tg-bovg-SE0410-Ab-2 | Anti-Bovine PLA2G15 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0410-Ab-1/ GM-Tg-equg-SE0410-Ab-2 | Anti-Equine PLA2G15 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0410-Ab-1/ GM-Tg-hg-SE0410-Ab-2; GM-Tg-rg-SE0410-Ab-1/ GM-Tg-rg-SE0410-Ab-2; GM-Tg-mg-SE0410-Ab-1/ GM-Tg-mg-SE0410-Ab-2; GM-Tg-cynog-SE0410-Ab-1/ GM-Tg-cynog-SE0410-Ab-2; GM-Tg-felg-SE0410-Ab-1/ GM-Tg-felg-SE0410-Ab-2; GM-Tg-cang-SE0410-Ab-1/ GM-Tg-cang-SE0410-Ab-2; GM-Tg-bovg-SE0410-Ab-1/ GM-Tg-bovg-SE0410-Ab-2; GM-Tg-equg-SE0410-Ab-1/ GM-Tg-equg-SE0410-Ab-2 |
| Products Name | Anti-PLA2G15 monoclonal antibody |
| Format | mab |
| Target Name | PLA2G15 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PLA2G15 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0410-Ag-1 | Recombinant multi-species PAG15/ PLA2G15/ ACS protein |
Target information
| Target ID | GM-SE0410 |
| Target Name | PLA2G15 |
| Gene ID | 23659,192654,361401,702619,403403,101092977,282271,100053908 |
| Gene Symbol and Synonyms | 1-O-acylceramidesynthase,ACS,GXVPLA2,LLPL,LPLA2,LYPLA3,PLA2G15 |
| Uniprot Accession | Q8NCC3,Q675A5,Q6XPZ3,Q8WMP9 |
| Uniprot Entry Name | PAG15_HUMAN,PAG15_RAT,PAG15_CANLF,PAG15_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000103066 |
| Target Classification | N/A |
The target: PLA2G15, gene name: PLA2G15, also named as ACS, GXVPLA2, LLPL, LPLA2, LYPLA3. Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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