Anti-MCH/ PMCH/ ppMCH functional antibody

Anti-MCH/ PMCH/ ppMCH functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to PMCH/PMCH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0418-Ab-1/ GM-Tg-hg-SE0418-Ab-2Anti-Human PMCH monoclonal antibodyHuman
GM-Tg-rg-SE0418-Ab-1/ GM-Tg-rg-SE0418-Ab-2Anti-Rat PMCH monoclonal antibodyRat
GM-Tg-mg-SE0418-Ab-1/ GM-Tg-mg-SE0418-Ab-2Anti-Mouse PMCH monoclonal antibodyMouse
GM-Tg-cynog-SE0418-Ab-1/ GM-Tg-cynog-SE0418-Ab-2Anti-Cynomolgus/ Rhesus macaque PMCH monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0418-Ab-1/ GM-Tg-felg-SE0418-Ab-2Anti-Feline PMCH monoclonal antibodyFeline
GM-Tg-cang-SE0418-Ab-1/ GM-Tg-cang-SE0418-Ab-2Anti-Canine PMCH monoclonal antibodyCanine
GM-Tg-bovg-SE0418-Ab-1/ GM-Tg-bovg-SE0418-Ab-2Anti-Bovine PMCH monoclonal antibodyBovine
GM-Tg-equg-SE0418-Ab-1/ GM-Tg-equg-SE0418-Ab-2Anti-Equine PMCH monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0418-Ab-1/ GM-Tg-hg-SE0418-Ab-2; GM-Tg-rg-SE0418-Ab-1/ GM-Tg-rg-SE0418-Ab-2;
GM-Tg-mg-SE0418-Ab-1/ GM-Tg-mg-SE0418-Ab-2; GM-Tg-cynog-SE0418-Ab-1/ GM-Tg-cynog-SE0418-Ab-2;
GM-Tg-felg-SE0418-Ab-1/ GM-Tg-felg-SE0418-Ab-2; GM-Tg-cang-SE0418-Ab-1/ GM-Tg-cang-SE0418-Ab-2;
GM-Tg-bovg-SE0418-Ab-1/ GM-Tg-bovg-SE0418-Ab-2; GM-Tg-equg-SE0418-Ab-1/ GM-Tg-equg-SE0418-Ab-2
Products NameAnti-PMCH monoclonal antibody
Formatmab
Target NamePMCH
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PMCH benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0418-Ag-1Recombinant multi-species MCH/ PMCH/ ppMCH protein


    Target information

    Target IDGM-SE0418
    Target NamePMCH
    Gene ID5367,110312,24659,107000992,449022,101100983,508013,100053268
    Gene Symbol and SynonymsA230109K23Rik,MCH,PMCH,ppMCH
    Uniprot AccessionP20382,P14200,Q5XXR2
    Uniprot Entry NameMCH_HUMAN,MCH_RAT,MCH_CANLF
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000183395
    Target ClassificationN/A

    The target: PMCH, gene name: PMCH, also named as MCH, ppMCH. This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include melanin-concentrating hormone (MCH), neuropeptide-glutamic acid-isoleucine (NEI), and neuropeptide-glycine-glutamic acid (NGE). Melanin-concentrating hormone is a 19-amino acid neuropeptide that stimulates hunger and may additionally regulate energy homeostasis, reproductive function, and sleep. Pseudogenes of this gene have been identified on chromosome 5. [provided by RefSeq, Jul 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.