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Anti-PRG2/ BMPG/ MBP functional antibody
Anti-PRG2/ BMPG/ MBP functional antibody for cell culture, ELISA & in-vivo assay
Go to PRG2/PRG2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0428-Ab-1/ GM-Tg-hg-SE0428-Ab-2 | Anti-Human PRG2 monoclonal antibody | Human |
| GM-Tg-rg-SE0428-Ab-1/ GM-Tg-rg-SE0428-Ab-2 | Anti-Rat PRG2 monoclonal antibody | Rat |
| GM-Tg-mg-SE0428-Ab-1/ GM-Tg-mg-SE0428-Ab-2 | Anti-Mouse PRG2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0428-Ab-1/ GM-Tg-cynog-SE0428-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PRG2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0428-Ab-1/ GM-Tg-felg-SE0428-Ab-2 | Anti-Feline PRG2 monoclonal antibody | Feline |
| GM-Tg-cang-SE0428-Ab-1/ GM-Tg-cang-SE0428-Ab-2 | Anti-Canine PRG2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0428-Ab-1/ GM-Tg-bovg-SE0428-Ab-2 | Anti-Bovine PRG2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0428-Ab-1/ GM-Tg-equg-SE0428-Ab-2 | Anti-Equine PRG2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0428-Ab-1/ GM-Tg-hg-SE0428-Ab-2; GM-Tg-rg-SE0428-Ab-1/ GM-Tg-rg-SE0428-Ab-2; GM-Tg-mg-SE0428-Ab-1/ GM-Tg-mg-SE0428-Ab-2; GM-Tg-cynog-SE0428-Ab-1/ GM-Tg-cynog-SE0428-Ab-2; GM-Tg-felg-SE0428-Ab-1/ GM-Tg-felg-SE0428-Ab-2; GM-Tg-cang-SE0428-Ab-1/ GM-Tg-cang-SE0428-Ab-2; GM-Tg-bovg-SE0428-Ab-1/ GM-Tg-bovg-SE0428-Ab-2; GM-Tg-equg-SE0428-Ab-1/ GM-Tg-equg-SE0428-Ab-2 |
| Products Name | Anti-PRG2 monoclonal antibody |
| Format | mab |
| Target Name | PRG2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PRG2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0428-Ag-1 | Recombinant multi-species PRG2/ BMPG/ MBP protein |
Target information
| Target ID | GM-SE0428 |
| Target Name | PRG2 |
| Gene ID | 5553,19074,58826,100423556 |
| Gene Symbol and Synonyms | BMPG,EMBP,MBP,MBP1,mMBP,mMBP-1,PRG2,proMBP |
| Uniprot Accession | P13727,Q63189 |
| Uniprot Entry Name | PRG2_HUMAN,PRG2_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000186652 |
| Target Classification | N/A |
The target: PRG2, gene name: PRG2, also named as BMPG, MBP, MBP1, proMBP. The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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