Anti-PSMD2/ P97/ RPN1 functional antibody
Anti-PSMD2/ P97/ RPN1 functional antibody for cell culture, ELISA & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-SE0437-Ab-1/ GM-Tg-hg-SE0437-Ab-2 | Anti-Human PSMD2 monoclonal antibody | Human |
GM-Tg-rg-SE0437-Ab-1/ GM-Tg-rg-SE0437-Ab-2 | Anti-Rat PSMD2 monoclonal antibody | Rat |
GM-Tg-mg-SE0437-Ab-1/ GM-Tg-mg-SE0437-Ab-2 | Anti-Mouse PSMD2 monoclonal antibody | Mouse |
GM-Tg-cynog-SE0437-Ab-1/ GM-Tg-cynog-SE0437-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PSMD2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-SE0437-Ab-1/ GM-Tg-felg-SE0437-Ab-2 | Anti-Feline PSMD2 monoclonal antibody | Feline |
GM-Tg-cang-SE0437-Ab-1/ GM-Tg-cang-SE0437-Ab-2 | Anti-Canine PSMD2 monoclonal antibody | Canine |
GM-Tg-bovg-SE0437-Ab-1/ GM-Tg-bovg-SE0437-Ab-2 | Anti-Bovine PSMD2 monoclonal antibody | Bovine |
GM-Tg-equg-SE0437-Ab-1/ GM-Tg-equg-SE0437-Ab-2 | Anti-Equine PSMD2 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-SE0437-Ab-1/ GM-Tg-hg-SE0437-Ab-2; GM-Tg-rg-SE0437-Ab-1/ GM-Tg-rg-SE0437-Ab-2; GM-Tg-mg-SE0437-Ab-1/ GM-Tg-mg-SE0437-Ab-2; GM-Tg-cynog-SE0437-Ab-1/ GM-Tg-cynog-SE0437-Ab-2; GM-Tg-felg-SE0437-Ab-1/ GM-Tg-felg-SE0437-Ab-2; GM-Tg-cang-SE0437-Ab-1/ GM-Tg-cang-SE0437-Ab-2; GM-Tg-bovg-SE0437-Ab-1/ GM-Tg-bovg-SE0437-Ab-2; GM-Tg-equg-SE0437-Ab-1/ GM-Tg-equg-SE0437-Ab-2 |
Products Name | Anti-PSMD2 monoclonal antibody |
Format | mab |
Target Name | PSMD2 |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category of antibody | FACS/Biofunctional Antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-PSMD2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-SE0437-Ag-1 | Recombinant multi-species PSMD2/ P97/ RPN1 protein |
ORF Viral Vector | pGMAD000442 | human PSMD2 Adenovirus plasmid |
ORF Viral Vector | pGMAD000148 | human PSMD2 Adenovirus plasmid |
ORF Viral Vector | vGMAD000442 | human PSMD2 Adenovirus particle |
ORF Viral Vector | vGMAD000148 | human PSMD2 Adenovirus particle |
Target information
Target ID | GM-SE0437 |
Target Name | PSMD2 |
Gene ID | 5708,21762,287984,705035,478654,101095190,539784,100059081 |
Gene Symbol and Synonyms | 9430095H01Rik,P97,PSMD2,RPN1,S2,TEG-190,Tex190,TRAP2 |
Uniprot Accession | Q13200,Q4FZT9,P56701 |
Uniprot Entry Name | PSMD2_HUMAN,PSMD2_RAT,PSMD2_BOVIN |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category | |
Disease | N/A |
Gene Ensembl | ENSG00000175166 |
Target Classification | N/A |
The target: PSMD2, gene name: PSMD2, also named as P97, RPN1, S2, TRAP2. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.