Anti-PXDN/ ASGD7/ COPOA functional antibody

Anti-PXDN/ ASGD7/ COPOA functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to PXDN/PXDN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0439-Ab-1/ GM-Tg-hg-SE0439-Ab-2Anti-Human PXDN monoclonal antibodyHuman
GM-Tg-rg-SE0439-Ab-1/ GM-Tg-rg-SE0439-Ab-2Anti-Rat PXDN monoclonal antibodyRat
GM-Tg-mg-SE0439-Ab-1/ GM-Tg-mg-SE0439-Ab-2Anti-Mouse PXDN monoclonal antibodyMouse
GM-Tg-cynog-SE0439-Ab-1/ GM-Tg-cynog-SE0439-Ab-2Anti-Cynomolgus/ Rhesus macaque PXDN monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0439-Ab-1/ GM-Tg-felg-SE0439-Ab-2Anti-Feline PXDN monoclonal antibodyFeline
GM-Tg-cang-SE0439-Ab-1/ GM-Tg-cang-SE0439-Ab-2Anti-Canine PXDN monoclonal antibodyCanine
GM-Tg-bovg-SE0439-Ab-1/ GM-Tg-bovg-SE0439-Ab-2Anti-Bovine PXDN monoclonal antibodyBovine
GM-Tg-equg-SE0439-Ab-1/ GM-Tg-equg-SE0439-Ab-2Anti-Equine PXDN monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0439-Ab-1/ GM-Tg-hg-SE0439-Ab-2; GM-Tg-rg-SE0439-Ab-1/ GM-Tg-rg-SE0439-Ab-2;
GM-Tg-mg-SE0439-Ab-1/ GM-Tg-mg-SE0439-Ab-2; GM-Tg-cynog-SE0439-Ab-1/ GM-Tg-cynog-SE0439-Ab-2;
GM-Tg-felg-SE0439-Ab-1/ GM-Tg-felg-SE0439-Ab-2; GM-Tg-cang-SE0439-Ab-1/ GM-Tg-cang-SE0439-Ab-2;
GM-Tg-bovg-SE0439-Ab-1/ GM-Tg-bovg-SE0439-Ab-2; GM-Tg-equg-SE0439-Ab-1/ GM-Tg-equg-SE0439-Ab-2
Products NameAnti-PXDN monoclonal antibody
Formatmab
Target NamePXDN
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PXDN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0439-Ag-1Recombinant multi-species PXDN/ ASGD7/ COPOA protein


    Target information

    Target IDGM-SE0439
    Target NamePXDN
    Gene ID7837,69675,554172,721659,100687809,101098455,515860,100072948
    Gene Symbol and Synonyms2310075M15Rik,ASGD7,COPOA,D2S448,D2S448E,E330004E07,hsPxd01,MG50,mKIAA0230,Perc64,PRG2,PXDN,PXN,VPO,VPO1
    Uniprot AccessionQ92626
    Uniprot Entry NamePXDN_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000130508
    Target ClassificationN/A

    The target: PXDN, gene name: PXDN, also named as ASGD7, COPOA, D2S448, D2S448E, MG50, PRG2, PXN, VPO. This gene encodes a heme-containing peroxidase that is secreted into the extracellular matrix. It is involved in extracellular matrix formation, and may function in the physiological and pathological fibrogenic response in fibrotic kidney. Mutations in this gene cause corneal opacification and other ocular anomalies, and also microphthalmia and anterior segment dysgenesis. [provided by RefSeq, Aug 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.