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Anti-RIC3/ AYST720/ PRO1385 functional antibody
Anti-RIC3/ AYST720/ PRO1385 functional antibody for cell culture, ELISA & in-vivo assay
Go to RIC3/RIC3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0445-Ab-1/ GM-Tg-hg-SE0445-Ab-2 | Anti-Human RIC3 monoclonal antibody | Human |
| GM-Tg-rg-SE0445-Ab-1/ GM-Tg-rg-SE0445-Ab-2 | Anti-Rat RIC3 monoclonal antibody | Rat |
| GM-Tg-mg-SE0445-Ab-1/ GM-Tg-mg-SE0445-Ab-2 | Anti-Mouse RIC3 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0445-Ab-1/ GM-Tg-cynog-SE0445-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RIC3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0445-Ab-1/ GM-Tg-felg-SE0445-Ab-2 | Anti-Feline RIC3 monoclonal antibody | Feline |
| GM-Tg-cang-SE0445-Ab-1/ GM-Tg-cang-SE0445-Ab-2 | Anti-Canine RIC3 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0445-Ab-1/ GM-Tg-bovg-SE0445-Ab-2 | Anti-Bovine RIC3 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0445-Ab-1/ GM-Tg-equg-SE0445-Ab-2 | Anti-Equine RIC3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0445-Ab-1/ GM-Tg-hg-SE0445-Ab-2; GM-Tg-rg-SE0445-Ab-1/ GM-Tg-rg-SE0445-Ab-2; GM-Tg-mg-SE0445-Ab-1/ GM-Tg-mg-SE0445-Ab-2; GM-Tg-cynog-SE0445-Ab-1/ GM-Tg-cynog-SE0445-Ab-2; GM-Tg-felg-SE0445-Ab-1/ GM-Tg-felg-SE0445-Ab-2; GM-Tg-cang-SE0445-Ab-1/ GM-Tg-cang-SE0445-Ab-2; GM-Tg-bovg-SE0445-Ab-1/ GM-Tg-bovg-SE0445-Ab-2; GM-Tg-equg-SE0445-Ab-1/ GM-Tg-equg-SE0445-Ab-2 |
| Products Name | Anti-RIC3 monoclonal antibody |
| Format | mab |
| Target Name | RIC3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-RIC3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0445-Ag-1 | Recombinant multi-species RIC3/ AYST720/ PRO1385 protein |
Target information
| Target ID | GM-SE0445 |
| Target Name | RIC3 |
| Gene ID | 79608,320360,687147,706162,611343,101090139,516280,100070915 |
| Gene Symbol and Synonyms | AYST720,E130307J04Rik,PRO1385,RIC-3,RIC3 |
| Uniprot Accession | Q7Z5B4 |
| Uniprot Entry Name | RIC3_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000166405 |
| Target Classification | N/A |
The target: RIC3, gene name: RIC3, also named as AYST720, PRO1385. This gene encodes a member of the resistance to inhibitors of cholinesterase 3-like family which functions as a chaperone of specific 5-hydroxytryptamine type 3 receptor and nicotinic acetylcholine receptor subtypes. The encoded protein influences the folding and assembly of these receptor subunits in the endoplasmic reticulum and expression on the cell surface. This protein contains an N-terminal transmembrane domain, a proline-rich spacer, and a cytosolic C-terminal coiled-coil domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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