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Anti-SEM3A/ SEMA3A/ COLL1 functional antibody
Anti-SEM3A/ SEMA3A/ COLL1 functional antibody for cell culture, ELISA & in-vivo assay
Go to SEMA3A/SEMA3A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0458-Ab-1/ GM-Tg-hg-SE0458-Ab-2 | Anti-Human SEMA3A monoclonal antibody | Human |
| GM-Tg-rg-SE0458-Ab-1/ GM-Tg-rg-SE0458-Ab-2 | Anti-Rat SEMA3A monoclonal antibody | Rat |
| GM-Tg-mg-SE0458-Ab-1/ GM-Tg-mg-SE0458-Ab-2 | Anti-Mouse SEMA3A monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0458-Ab-1/ GM-Tg-cynog-SE0458-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SEMA3A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0458-Ab-1/ GM-Tg-felg-SE0458-Ab-2 | Anti-Feline SEMA3A monoclonal antibody | Feline |
| GM-Tg-cang-SE0458-Ab-1/ GM-Tg-cang-SE0458-Ab-2 | Anti-Canine SEMA3A monoclonal antibody | Canine |
| GM-Tg-bovg-SE0458-Ab-1/ GM-Tg-bovg-SE0458-Ab-2 | Anti-Bovine SEMA3A monoclonal antibody | Bovine |
| GM-Tg-equg-SE0458-Ab-1/ GM-Tg-equg-SE0458-Ab-2 | Anti-Equine SEMA3A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0458-Ab-1/ GM-Tg-hg-SE0458-Ab-2; GM-Tg-rg-SE0458-Ab-1/ GM-Tg-rg-SE0458-Ab-2; GM-Tg-mg-SE0458-Ab-1/ GM-Tg-mg-SE0458-Ab-2; GM-Tg-cynog-SE0458-Ab-1/ GM-Tg-cynog-SE0458-Ab-2; GM-Tg-felg-SE0458-Ab-1/ GM-Tg-felg-SE0458-Ab-2; GM-Tg-cang-SE0458-Ab-1/ GM-Tg-cang-SE0458-Ab-2; GM-Tg-bovg-SE0458-Ab-1/ GM-Tg-bovg-SE0458-Ab-2; GM-Tg-equg-SE0458-Ab-1/ GM-Tg-equg-SE0458-Ab-2 |
| Products Name | Anti-SEMA3A monoclonal antibody |
| Format | mab |
| Target Name | SEMA3A |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SEMA3A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0458-Ag-1 | Recombinant multi-species SEM3A/ SEMA3A/ COLL1 protein |
| ORF Viral Vector | pGMLV000756 | house mouse Sema3a Lentivirus plasmid |
| ORF Viral Vector | vGMLV000756 | house mouse Sema3a Lentivirus particle |
Target information
| Target ID | GM-SE0458 |
| Target Name | SEMA3A |
| Gene ID | 10371,20346,29751,708263,483386,101094836,537777,100058155 |
| Gene Symbol and Synonyms | coll-1,COLL1,HH16,Hsema-I,Hsema-III,SEMA1,SEMA3A,SEMAD,SEMAIII,SEMAL,SemD |
| Uniprot Accession | Q14563,Q63548 |
| Uniprot Entry Name | SEM3A_HUMAN,SEM3A_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Acute kidney failure |
| Gene Ensembl | ENSG00000075213 |
| Target Classification | N/A |
The target: SEMA3A, gene name: SEMA3A, also named as COLL1, HH16, Hsema-I, Hsema-III, SEMA1, SEMAD, SEMAIII, SEMAL, SemD, coll-1. This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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