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Anti-PSPC/ SFTPC/ BRICD6 functional antibody
Anti-PSPC/ SFTPC/ BRICD6 functional antibody for cell culture, ELISA & in-vivo assay
Go to SFTPC/SFTPC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0471-Ab-1/ GM-Tg-hg-SE0471-Ab-2 | Anti-Human SFTPC monoclonal antibody | Human |
| GM-Tg-rg-SE0471-Ab-1/ GM-Tg-rg-SE0471-Ab-2 | Anti-Rat SFTPC monoclonal antibody | Rat |
| GM-Tg-mg-SE0471-Ab-1/ GM-Tg-mg-SE0471-Ab-2 | Anti-Mouse SFTPC monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0471-Ab-1/ GM-Tg-cynog-SE0471-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SFTPC monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0471-Ab-1/ GM-Tg-felg-SE0471-Ab-2 | Anti-Feline SFTPC monoclonal antibody | Feline |
| GM-Tg-cang-SE0471-Ab-1/ GM-Tg-cang-SE0471-Ab-2 | Anti-Canine SFTPC monoclonal antibody | Canine |
| GM-Tg-bovg-SE0471-Ab-1/ GM-Tg-bovg-SE0471-Ab-2 | Anti-Bovine SFTPC monoclonal antibody | Bovine |
| GM-Tg-equg-SE0471-Ab-1/ GM-Tg-equg-SE0471-Ab-2 | Anti-Equine SFTPC monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0471-Ab-1/ GM-Tg-hg-SE0471-Ab-2; GM-Tg-rg-SE0471-Ab-1/ GM-Tg-rg-SE0471-Ab-2; GM-Tg-mg-SE0471-Ab-1/ GM-Tg-mg-SE0471-Ab-2; GM-Tg-cynog-SE0471-Ab-1/ GM-Tg-cynog-SE0471-Ab-2; GM-Tg-felg-SE0471-Ab-1/ GM-Tg-felg-SE0471-Ab-2; GM-Tg-cang-SE0471-Ab-1/ GM-Tg-cang-SE0471-Ab-2; GM-Tg-bovg-SE0471-Ab-1/ GM-Tg-bovg-SE0471-Ab-2; GM-Tg-equg-SE0471-Ab-1/ GM-Tg-equg-SE0471-Ab-2 |
| Products Name | Anti-SFTPC monoclonal antibody |
| Format | mab |
| Target Name | SFTPC |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SFTPC benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0471-Ag-1 | Recombinant multi-species PSPC/ SFTPC/ BRICD6 protein |
| ORF Viral Vector | pGMLP004809 | human SFTPC Lentivirus plasmid |
| ORF Viral Vector | vGMLP004809 | human SFTPC Lentivirus particle |
| ORF Viral Vector | pGMLPm000976 | mouse Sftpc Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000976 | mouse Sftpc Lentivirus particle |
Target information
| Target ID | GM-SE0471 |
| Target Name | SFTPC |
| Gene ID | 6440,20389,50683,707696,477385,101089602,282071,100053773 |
| Gene Symbol and Synonyms | BRICD6,pro-SpC,PSP-C,Sftp-2,SFTP2,SFTPC,SMDP2,SP-C,SP5,SPC |
| Uniprot Accession | P11686,P11685,P55152,P22397,P15783 |
| Uniprot Entry Name | PSPC_HUMAN,PSPC_MACMU,PSPC_RAT,PSPC_CANLF,PSPC_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Lung Cancer |
| Gene Ensembl | ENSG00000168484 |
| Target Classification | N/A |
The target: SFTPC, gene name: SFTPC, also named as BRICD6, PSP-C, SFTP2, SMDP2, SP-C. This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.[provided by RefSeq, Feb 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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