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Anti-SLIT2/ SLIL3/ Slit-2 functional antibody
Anti-SLIT2/ SLIL3/ Slit-2 functional antibody for cell culture, ELISA & in-vivo assay
Go to SLIT2/SLIT2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0474-Ab-1/ GM-Tg-hg-SE0474-Ab-2 | Anti-Human SLIT2 monoclonal antibody | Human |
| GM-Tg-rg-SE0474-Ab-1/ GM-Tg-rg-SE0474-Ab-2 | Anti-Rat SLIT2 monoclonal antibody | Rat |
| GM-Tg-mg-SE0474-Ab-1/ GM-Tg-mg-SE0474-Ab-2 | Anti-Mouse SLIT2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0474-Ab-1/ GM-Tg-cynog-SE0474-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SLIT2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0474-Ab-1/ GM-Tg-felg-SE0474-Ab-2 | Anti-Feline SLIT2 monoclonal antibody | Feline |
| GM-Tg-cang-SE0474-Ab-1/ GM-Tg-cang-SE0474-Ab-2 | Anti-Canine SLIT2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0474-Ab-1/ GM-Tg-bovg-SE0474-Ab-2 | Anti-Bovine SLIT2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0474-Ab-1/ GM-Tg-equg-SE0474-Ab-2 | Anti-Equine SLIT2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0474-Ab-1/ GM-Tg-hg-SE0474-Ab-2; GM-Tg-rg-SE0474-Ab-1/ GM-Tg-rg-SE0474-Ab-2; GM-Tg-mg-SE0474-Ab-1/ GM-Tg-mg-SE0474-Ab-2; GM-Tg-cynog-SE0474-Ab-1/ GM-Tg-cynog-SE0474-Ab-2; GM-Tg-felg-SE0474-Ab-1/ GM-Tg-felg-SE0474-Ab-2; GM-Tg-cang-SE0474-Ab-1/ GM-Tg-cang-SE0474-Ab-2; GM-Tg-bovg-SE0474-Ab-1/ GM-Tg-bovg-SE0474-Ab-2; GM-Tg-equg-SE0474-Ab-1/ GM-Tg-equg-SE0474-Ab-2 |
| Products Name | Anti-SLIT2 monoclonal antibody |
| Format | mab |
| Target Name | SLIT2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SLIT2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0474-Ag-1 | Recombinant multi-species SLIT2/ SLIL3/ Slit-2 protein |
| ORF Viral Vector | pGMAD000112 | mouse Slit2 Adenovirus plasmid |
| ORF Viral Vector | vGMAD000112 | mouse Slit2 Adenovirus particle |
Target information
| Target ID | GM-SE0474 |
| Target Name | SLIT2 |
| Gene ID | 9353,20563,360272,715470,595148,101084791,534164,100068338 |
| Gene Symbol and Synonyms | b2b1200.1Clo,Drad-1,E030015M03Rik,E130320P19Rik,mKIAA4141,SLIL3,Slit-2,SLIT2 |
| Uniprot Accession | O94813,Q9WVC1 |
| Uniprot Entry Name | SLIT2_HUMAN,SLIT2_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000145147 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: SLIT2, gene name: SLIT2, also named as SLIL3, Slit-2. This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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