Anti-ISK6/ SPINK6/ BUSI2 functional antibody

Anti-ISK6/ SPINK6/ BUSI2 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to SPINK6/SPINK6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0482-Ab-1/ GM-Tg-hg-SE0482-Ab-2Anti-Human SPINK6 monoclonal antibodyHuman
GM-Tg-rg-SE0482-Ab-1/ GM-Tg-rg-SE0482-Ab-2Anti-Rat SPINK6 monoclonal antibodyRat
GM-Tg-mg-SE0482-Ab-1/ GM-Tg-mg-SE0482-Ab-2Anti-Mouse SPINK6 monoclonal antibodyMouse
GM-Tg-cynog-SE0482-Ab-1/ GM-Tg-cynog-SE0482-Ab-2Anti-Cynomolgus/ Rhesus macaque SPINK6 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0482-Ab-1/ GM-Tg-felg-SE0482-Ab-2Anti-Feline SPINK6 monoclonal antibodyFeline
GM-Tg-cang-SE0482-Ab-1/ GM-Tg-cang-SE0482-Ab-2Anti-Canine SPINK6 monoclonal antibodyCanine
GM-Tg-bovg-SE0482-Ab-1/ GM-Tg-bovg-SE0482-Ab-2Anti-Bovine SPINK6 monoclonal antibodyBovine
GM-Tg-equg-SE0482-Ab-1/ GM-Tg-equg-SE0482-Ab-2Anti-Equine SPINK6 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0482-Ab-1/ GM-Tg-hg-SE0482-Ab-2; GM-Tg-rg-SE0482-Ab-1/ GM-Tg-rg-SE0482-Ab-2;
GM-Tg-mg-SE0482-Ab-1/ GM-Tg-mg-SE0482-Ab-2; GM-Tg-cynog-SE0482-Ab-1/ GM-Tg-cynog-SE0482-Ab-2;
GM-Tg-felg-SE0482-Ab-1/ GM-Tg-felg-SE0482-Ab-2; GM-Tg-cang-SE0482-Ab-1/ GM-Tg-cang-SE0482-Ab-2;
GM-Tg-bovg-SE0482-Ab-1/ GM-Tg-bovg-SE0482-Ab-2; GM-Tg-equg-SE0482-Ab-1/ GM-Tg-equg-SE0482-Ab-2
Products NameAnti-SPINK6 monoclonal antibody
Formatmab
Target NameSPINK6
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SPINK6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0482-Ag-1Recombinant multi-species ISK6/ SPINK6/ BUSI2 protein


    Target information

    Target IDGM-SE0482
    Target NameSPINK6
    Gene ID404203,433180,408235,709586,100685732,101086945
    Gene Symbol and SynonymsBUSI2,EG433180,Spink5l1,SPINK6,UNQ844
    Uniprot AccessionQ6UWN8,Q6IE47
    Uniprot Entry NameISK6_HUMAN,ISK6_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000178172
    Target ClassificationN/A

    The target: SPINK6, gene name: SPINK6, also named as BUSI2, UNQ844. The protein encoded by this gene is a Kazal-type serine protease inhibitor that acts on kallikrein-related peptidases in the skin. Two transcript variants the same protein have been found for this gene. [provided by RefSeq, Aug 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.