Anti-ISK9/ SPINK9/ LEKTI2 functional antibody

Anti-ISK9/ SPINK9/ LEKTI2 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to SPINK9/SPINK9 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0483-Ab-1/ GM-Tg-hg-SE0483-Ab-2Anti-Human SPINK9 monoclonal antibodyHuman
GM-Tg-rg-SE0483-Ab-1/ GM-Tg-rg-SE0483-Ab-2Anti-Rat SPINK9 monoclonal antibodyRat
GM-Tg-mg-SE0483-Ab-1/ GM-Tg-mg-SE0483-Ab-2Anti-Mouse SPINK9 monoclonal antibodyMouse
GM-Tg-cynog-SE0483-Ab-1/ GM-Tg-cynog-SE0483-Ab-2Anti-Cynomolgus/ Rhesus macaque SPINK9 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0483-Ab-1/ GM-Tg-felg-SE0483-Ab-2Anti-Feline SPINK9 monoclonal antibodyFeline
GM-Tg-cang-SE0483-Ab-1/ GM-Tg-cang-SE0483-Ab-2Anti-Canine SPINK9 monoclonal antibodyCanine
GM-Tg-bovg-SE0483-Ab-1/ GM-Tg-bovg-SE0483-Ab-2Anti-Bovine SPINK9 monoclonal antibodyBovine
GM-Tg-equg-SE0483-Ab-1/ GM-Tg-equg-SE0483-Ab-2Anti-Equine SPINK9 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0483-Ab-1/ GM-Tg-hg-SE0483-Ab-2; GM-Tg-rg-SE0483-Ab-1/ GM-Tg-rg-SE0483-Ab-2;
GM-Tg-mg-SE0483-Ab-1/ GM-Tg-mg-SE0483-Ab-2; GM-Tg-cynog-SE0483-Ab-1/ GM-Tg-cynog-SE0483-Ab-2;
GM-Tg-felg-SE0483-Ab-1/ GM-Tg-felg-SE0483-Ab-2; GM-Tg-cang-SE0483-Ab-1/ GM-Tg-cang-SE0483-Ab-2;
GM-Tg-bovg-SE0483-Ab-1/ GM-Tg-bovg-SE0483-Ab-2; GM-Tg-equg-SE0483-Ab-1/ GM-Tg-equg-SE0483-Ab-2
Products NameAnti-SPINK9 monoclonal antibody
Formatmab
Target NameSPINK9
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SPINK9 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0483-Ag-1Recombinant multi-species ISK9/ SPINK9/ LEKTI2 protein


    Target information

    Target IDGM-SE0483
    Target NameSPINK9
    Gene ID643394,708270,100630751
    Gene Symbol and SynonymsLEKTI2,SPINK9
    Uniprot AccessionQ5DT21
    Uniprot Entry NameISK9_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000204909
    Target ClassificationN/A

    The target: SPINK9, gene name: SPINK9, also named as LEKTI2. The protein encoded by this gene is a Kazal-type serine protease inhibitor that appears to specifically target kallikrein-related peptidase 5 (KLK5) in the palmo-plantar epidermis. KLK5 is an important initiator of skin desquamation, so the encoded protease inhibitor may regulate skin differentiation in the palms of hands and soles of feet. This cationic protein has also been shown to promote keratinocyte migration by activation of the epidermal growth factor receptor (EGFR). [provided by RefSeq, Dec 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.