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Anti-TENX/ TNXB/ EDS3 functional antibody
Anti-TENX/ TNXB/ EDS3 functional antibody for cell culture, ELISA & in-vivo assay
Go to TNXB/TNXB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0520-Ab-1/ GM-Tg-hg-SE0520-Ab-2 | Anti-Human TNXB monoclonal antibody | Human |
| GM-Tg-rg-SE0520-Ab-1/ GM-Tg-rg-SE0520-Ab-2 | Anti-Rat TNXB monoclonal antibody | Rat |
| GM-Tg-mg-SE0520-Ab-1/ GM-Tg-mg-SE0520-Ab-2 | Anti-Mouse TNXB monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0520-Ab-1/ GM-Tg-cynog-SE0520-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TNXB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0520-Ab-1/ GM-Tg-felg-SE0520-Ab-2 | Anti-Feline TNXB monoclonal antibody | Feline |
| GM-Tg-cang-SE0520-Ab-1/ GM-Tg-cang-SE0520-Ab-2 | Anti-Canine TNXB monoclonal antibody | Canine |
| GM-Tg-bovg-SE0520-Ab-1/ GM-Tg-bovg-SE0520-Ab-2 | Anti-Bovine TNXB monoclonal antibody | Bovine |
| GM-Tg-equg-SE0520-Ab-1/ GM-Tg-equg-SE0520-Ab-2 | Anti-Equine TNXB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0520-Ab-1/ GM-Tg-hg-SE0520-Ab-2; GM-Tg-rg-SE0520-Ab-1/ GM-Tg-rg-SE0520-Ab-2; GM-Tg-mg-SE0520-Ab-1/ GM-Tg-mg-SE0520-Ab-2; GM-Tg-cynog-SE0520-Ab-1/ GM-Tg-cynog-SE0520-Ab-2; GM-Tg-felg-SE0520-Ab-1/ GM-Tg-felg-SE0520-Ab-2; GM-Tg-cang-SE0520-Ab-1/ GM-Tg-cang-SE0520-Ab-2; GM-Tg-bovg-SE0520-Ab-1/ GM-Tg-bovg-SE0520-Ab-2; GM-Tg-equg-SE0520-Ab-1/ GM-Tg-equg-SE0520-Ab-2 |
| Products Name | Anti-TNXB monoclonal antibody |
| Format | mab |
| Target Name | TNXB |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TNXB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0520-Ag-1 | Recombinant multi-species TENX/ TNXB/ EDS3 protein |
Target information
| Target ID | GM-SE0520 |
| Target Name | TNXB |
| Gene ID | 7148,81877,716998,100682877,101101563,282654,100059315 |
| Gene Symbol and Synonyms | EDS3,EDSCLL,EDSCLL1,HXBL,TENX,Tn-mhc,TN-X,TNX,TNXB,TNXB1,TNXB2,TNXBS,VUR8,XB,XBS |
| Uniprot Accession | P22105 |
| Uniprot Entry Name | TENX_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000168477 |
| Target Classification | N/A |
The target: TNXB, gene name: TNXB, also named as EDS3, EDSCLL, EDSCLL1, HXBL, TENX, TN-X, TNX1, TNXB2, TNXBS, VUR8, XB, XBS, TNXB. This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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