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Anti-UBXN8/ D8S2298E/ REP8 functional antibody
Anti-UBXN8/ D8S2298E/ REP8 functional antibody for cell culture, ELISA & in-vivo assay
Go to UBXN8/UBXN8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0532-Ab-1/ GM-Tg-hg-SE0532-Ab-2 | Anti-Human UBXN8 monoclonal antibody | Human |
| GM-Tg-rg-SE0532-Ab-1/ GM-Tg-rg-SE0532-Ab-2 | Anti-Rat UBXN8 monoclonal antibody | Rat |
| GM-Tg-mg-SE0532-Ab-1/ GM-Tg-mg-SE0532-Ab-2 | Anti-Mouse UBXN8 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0532-Ab-1/ GM-Tg-cynog-SE0532-Ab-2 | Anti-Cynomolgus/ Rhesus macaque UBXN8 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0532-Ab-1/ GM-Tg-felg-SE0532-Ab-2 | Anti-Feline UBXN8 monoclonal antibody | Feline |
| GM-Tg-cang-SE0532-Ab-1/ GM-Tg-cang-SE0532-Ab-2 | Anti-Canine UBXN8 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0532-Ab-1/ GM-Tg-bovg-SE0532-Ab-2 | Anti-Bovine UBXN8 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0532-Ab-1/ GM-Tg-equg-SE0532-Ab-2 | Anti-Equine UBXN8 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0532-Ab-1/ GM-Tg-hg-SE0532-Ab-2; GM-Tg-rg-SE0532-Ab-1/ GM-Tg-rg-SE0532-Ab-2; GM-Tg-mg-SE0532-Ab-1/ GM-Tg-mg-SE0532-Ab-2; GM-Tg-cynog-SE0532-Ab-1/ GM-Tg-cynog-SE0532-Ab-2; GM-Tg-felg-SE0532-Ab-1/ GM-Tg-felg-SE0532-Ab-2; GM-Tg-cang-SE0532-Ab-1/ GM-Tg-cang-SE0532-Ab-2; GM-Tg-bovg-SE0532-Ab-1/ GM-Tg-bovg-SE0532-Ab-2; GM-Tg-equg-SE0532-Ab-1/ GM-Tg-equg-SE0532-Ab-2 |
| Products Name | Anti-UBXN8 monoclonal antibody |
| Format | mab |
| Target Name | UBXN8 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-UBXN8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0532-Ag-1 | Recombinant multi-species UBXN8/ D8S2298E/ REP8 protein |
Target information
| Target ID | GM-SE0532 |
| Target Name | UBXN8 |
| Gene ID | 7993,108159,290802,695825,475595,101090764,509646,100058282 |
| Gene Symbol and Synonyms | D0H8S2298E,D8S2298E,Rep-8,REP8,Rep8h,RGD1306023,UBXD6,UBXN8 |
| Uniprot Accession | O00124,Q2TBH5 |
| Uniprot Entry Name | UBXN8_HUMAN,UBXN8_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000104691 |
| Target Classification | N/A |
The target: UBXN8, gene name: UBXN8, also named as D8S2298E, REP8, UBXD6. p97 or VCP (valosin-containing protein) is a versatile ATPase complex, and many cofactors are required for the p97 functional diversity. This gene encodes one of the p97 cofactors. This cofactor is a transmembrane protein and localized in the endoplasmic reticulum (ER) membrane. It tethers p97 to the ER membrane via its UBX domain. The association of this cofactor with p97 facilitates efficient ER-associated degradation of misfolded proteins. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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