Anti-UROM/ UMOD/ ADMCKD2 functional antibody

Anti-UROM/ UMOD/ ADMCKD2 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to UMOD/UMOD products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0538-Ab-1/ GM-Tg-hg-SE0538-Ab-2Anti-Human UMOD monoclonal antibodyHuman
GM-Tg-rg-SE0538-Ab-1/ GM-Tg-rg-SE0538-Ab-2Anti-Rat UMOD monoclonal antibodyRat
GM-Tg-mg-SE0538-Ab-1/ GM-Tg-mg-SE0538-Ab-2Anti-Mouse UMOD monoclonal antibodyMouse
GM-Tg-cynog-SE0538-Ab-1/ GM-Tg-cynog-SE0538-Ab-2Anti-Cynomolgus/ Rhesus macaque UMOD monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0538-Ab-1/ GM-Tg-felg-SE0538-Ab-2Anti-Feline UMOD monoclonal antibodyFeline
GM-Tg-cang-SE0538-Ab-1/ GM-Tg-cang-SE0538-Ab-2Anti-Canine UMOD monoclonal antibodyCanine
GM-Tg-bovg-SE0538-Ab-1/ GM-Tg-bovg-SE0538-Ab-2Anti-Bovine UMOD monoclonal antibodyBovine
GM-Tg-equg-SE0538-Ab-1/ GM-Tg-equg-SE0538-Ab-2Anti-Equine UMOD monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0538-Ab-1/ GM-Tg-hg-SE0538-Ab-2; GM-Tg-rg-SE0538-Ab-1/ GM-Tg-rg-SE0538-Ab-2;
GM-Tg-mg-SE0538-Ab-1/ GM-Tg-mg-SE0538-Ab-2; GM-Tg-cynog-SE0538-Ab-1/ GM-Tg-cynog-SE0538-Ab-2;
GM-Tg-felg-SE0538-Ab-1/ GM-Tg-felg-SE0538-Ab-2; GM-Tg-cang-SE0538-Ab-1/ GM-Tg-cang-SE0538-Ab-2;
GM-Tg-bovg-SE0538-Ab-1/ GM-Tg-bovg-SE0538-Ab-2; GM-Tg-equg-SE0538-Ab-1/ GM-Tg-equg-SE0538-Ab-2
Products NameAnti-UMOD monoclonal antibody
Formatmab
Target NameUMOD
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-UMOD benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0538-Ag-1Recombinant multi-species UROM/ UMOD/ ADMCKD2 protein
    ORF Viral VectorvGMLP000719human UMOD Lentivirus particle
    ORF Viral VectorpGMLP000719human UMOD Lentivirus plasmid


    Target information

    Target IDGM-SE0538
    Target NameUMOD
    Gene ID7369,22242,25128,695883,403510,101084248,281567,100051746
    Gene Symbol and SynonymsADMCKD2,ADTKD1,FJHN,HNFJ,HNFJ1,MCKD2,THGP,THP,UMOD,Urehd1,urehr4
    Uniprot AccessionP07911,P27590,Q862Z3,P48733
    Uniprot Entry NameUROM_HUMAN,UROM_RAT,UROM_CANLF,UROM_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseDiabetic Nephropathy, Asphyxia neonatorum, Calculus of kidney, Complications of kidney transplant, Dent disease, IgA glomerulonephritis, Interstitial cystitis (chronic), Juvenile arthritis, Malignant neoplasm of bladder, Type 1 diabetes mellitus
    Gene EnsemblENSG00000169344
    Target ClassificationN/A

    The target: UMOD, gene name: UMOD, also named as ADMCKD2, FJHN, HNFJ, HNFJ1, MCKD2, THGP, THP. The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013].



    About Gmab

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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.