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Anti-CSPG2/ VCAN/ ERVR functional antibody
Anti-CSPG2/ VCAN/ ERVR functional antibody for cell culture, ELISA & in-vivo assay
Go to VCAN/VCAN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0543-Ab-1/ GM-Tg-hg-SE0543-Ab-2 | Anti-Human VCAN monoclonal antibody | Human |
| GM-Tg-rg-SE0543-Ab-1/ GM-Tg-rg-SE0543-Ab-2 | Anti-Rat VCAN monoclonal antibody | Rat |
| GM-Tg-mg-SE0543-Ab-1/ GM-Tg-mg-SE0543-Ab-2 | Anti-Mouse VCAN monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0543-Ab-1/ GM-Tg-cynog-SE0543-Ab-2 | Anti-Cynomolgus/ Rhesus macaque VCAN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0543-Ab-1/ GM-Tg-felg-SE0543-Ab-2 | Anti-Feline VCAN monoclonal antibody | Feline |
| GM-Tg-cang-SE0543-Ab-1/ GM-Tg-cang-SE0543-Ab-2 | Anti-Canine VCAN monoclonal antibody | Canine |
| GM-Tg-bovg-SE0543-Ab-1/ GM-Tg-bovg-SE0543-Ab-2 | Anti-Bovine VCAN monoclonal antibody | Bovine |
| GM-Tg-equg-SE0543-Ab-1/ GM-Tg-equg-SE0543-Ab-2 | Anti-Equine VCAN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0543-Ab-1/ GM-Tg-hg-SE0543-Ab-2; GM-Tg-rg-SE0543-Ab-1/ GM-Tg-rg-SE0543-Ab-2; GM-Tg-mg-SE0543-Ab-1/ GM-Tg-mg-SE0543-Ab-2; GM-Tg-cynog-SE0543-Ab-1/ GM-Tg-cynog-SE0543-Ab-2; GM-Tg-felg-SE0543-Ab-1/ GM-Tg-felg-SE0543-Ab-2; GM-Tg-cang-SE0543-Ab-1/ GM-Tg-cang-SE0543-Ab-2; GM-Tg-bovg-SE0543-Ab-1/ GM-Tg-bovg-SE0543-Ab-2; GM-Tg-equg-SE0543-Ab-1/ GM-Tg-equg-SE0543-Ab-2 |
| Products Name | Anti-VCAN monoclonal antibody |
| Format | mab |
| Target Name | VCAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-VCAN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0543-Ag-1 | Recombinant multi-species CSPG2/ VCAN/ ERVR protein |
Target information
| Target ID | GM-SE0543 |
| Target Name | VCAN |
| Gene ID | 1462,13003,114122,712365,488922,101093662,282662,100065275 |
| Gene Symbol and Synonyms | 5430420N07Rik,9430051N09,CSPG2,DPEAAE,ERVR,GHAP,hdf,NG2,PG-M,PG-M(V0),PG-M(V1),VCAN,WGN,WGN1 |
| Uniprot Accession | P13611,Q9ERB4,P81282 |
| Uniprot Entry Name | CSPG2_HUMAN,CSPG2_RAT,CSPG2_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Ovary Cancer |
| Gene Ensembl | ENSG00000038427 |
| Target Classification | N/A |
The target: VCAN, gene name: VCAN, also named as CSPG2, ERVR, GHAP, PG-M, WGN, WGN1. This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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