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Anti-XRCC6/ CTC75/ CTCBF functional antibody
Anti-XRCC6/ CTC75/ CTCBF functional antibody for cell culture, ELISA & in-vivo assay
Go to XRCC6/XRCC6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0563-Ab-1/ GM-Tg-hg-SE0563-Ab-2 | Anti-Human XRCC6 monoclonal antibody | Human |
| GM-Tg-rg-SE0563-Ab-1/ GM-Tg-rg-SE0563-Ab-2 | Anti-Rat XRCC6 monoclonal antibody | Rat |
| GM-Tg-mg-SE0563-Ab-1/ GM-Tg-mg-SE0563-Ab-2 | Anti-Mouse XRCC6 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0563-Ab-1/ GM-Tg-cynog-SE0563-Ab-2 | Anti-Cynomolgus/ Rhesus macaque XRCC6 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0563-Ab-1/ GM-Tg-felg-SE0563-Ab-2 | Anti-Feline XRCC6 monoclonal antibody | Feline |
| GM-Tg-cang-SE0563-Ab-1/ GM-Tg-cang-SE0563-Ab-2 | Anti-Canine XRCC6 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0563-Ab-1/ GM-Tg-bovg-SE0563-Ab-2 | Anti-Bovine XRCC6 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0563-Ab-1/ GM-Tg-equg-SE0563-Ab-2 | Anti-Equine XRCC6 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0563-Ab-1/ GM-Tg-hg-SE0563-Ab-2; GM-Tg-rg-SE0563-Ab-1/ GM-Tg-rg-SE0563-Ab-2; GM-Tg-mg-SE0563-Ab-1/ GM-Tg-mg-SE0563-Ab-2; GM-Tg-cynog-SE0563-Ab-1/ GM-Tg-cynog-SE0563-Ab-2; GM-Tg-felg-SE0563-Ab-1/ GM-Tg-felg-SE0563-Ab-2; GM-Tg-cang-SE0563-Ab-1/ GM-Tg-cang-SE0563-Ab-2; GM-Tg-bovg-SE0563-Ab-1/ GM-Tg-bovg-SE0563-Ab-2; GM-Tg-equg-SE0563-Ab-1/ GM-Tg-equg-SE0563-Ab-2 |
| Products Name | Anti-XRCC6 monoclonal antibody |
| Format | mab |
| Target Name | XRCC6 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-XRCC6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0563-Ag-1 | Recombinant multi-species XRCC6/ CTC75/ CTCBF protein |
| ORF Viral Vector | vGMLP002223 | human XRCC6 Lentivirus particle |
| ORF Viral Vector | pGMLP002223 | human XRCC6 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005063 | mouse Xrcc6 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005063 | mouse Xrcc6 Lentivirus particle |
Target information
| Target ID | GM-SE0563 |
| Target Name | XRCC6 |
| Gene ID | 2547,14375,25019,707975,474485,101081395,510132,100070684 |
| Gene Symbol and Synonyms | 70kDa,CTC75,CTCBF,G22P1,KU70,Kup70,ML8,TLAA,XRCC6 |
| Uniprot Accession | P12956 |
| Uniprot Entry Name | XRCC6_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000196419 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: XRCC6, gene name: XRCC6, also named as CTC75, CTCBF, G22P1, KU70, ML8, TLAA. The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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