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Anti-XYLT2/ PXYLT2/ SOS functional antibody
Anti-XYLT2/ PXYLT2/ SOS functional antibody for cell culture, ELISA & in-vivo assay
Go to XYLT2/XYLT2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0565-Ab-1/ GM-Tg-hg-SE0565-Ab-2 | Anti-Human XYLT2 monoclonal antibody | Human |
| GM-Tg-rg-SE0565-Ab-1/ GM-Tg-rg-SE0565-Ab-2 | Anti-Rat XYLT2 monoclonal antibody | Rat |
| GM-Tg-mg-SE0565-Ab-1/ GM-Tg-mg-SE0565-Ab-2 | Anti-Mouse XYLT2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0565-Ab-1/ GM-Tg-cynog-SE0565-Ab-2 | Anti-Cynomolgus/ Rhesus macaque XYLT2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0565-Ab-1/ GM-Tg-felg-SE0565-Ab-2 | Anti-Feline XYLT2 monoclonal antibody | Feline |
| GM-Tg-cang-SE0565-Ab-1/ GM-Tg-cang-SE0565-Ab-2 | Anti-Canine XYLT2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0565-Ab-1/ GM-Tg-bovg-SE0565-Ab-2 | Anti-Bovine XYLT2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0565-Ab-1/ GM-Tg-equg-SE0565-Ab-2 | Anti-Equine XYLT2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0565-Ab-1/ GM-Tg-hg-SE0565-Ab-2; GM-Tg-rg-SE0565-Ab-1/ GM-Tg-rg-SE0565-Ab-2; GM-Tg-mg-SE0565-Ab-1/ GM-Tg-mg-SE0565-Ab-2; GM-Tg-cynog-SE0565-Ab-1/ GM-Tg-cynog-SE0565-Ab-2; GM-Tg-felg-SE0565-Ab-1/ GM-Tg-felg-SE0565-Ab-2; GM-Tg-cang-SE0565-Ab-1/ GM-Tg-cang-SE0565-Ab-2; GM-Tg-bovg-SE0565-Ab-1/ GM-Tg-bovg-SE0565-Ab-2; GM-Tg-equg-SE0565-Ab-1/ GM-Tg-equg-SE0565-Ab-2 |
| Products Name | Anti-XYLT2 monoclonal antibody |
| Format | mab |
| Target Name | XYLT2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-XYLT2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0565-Ag-1 | Recombinant multi-species XYLT2/ PXYLT2/ SOS protein |
Target information
| Target ID | GM-SE0565 |
| Target Name | XYLT2 |
| Gene ID | 64132,217119,64134,705139,493990,101099511,493989,100069884 |
| Gene Symbol and Synonyms | E030002B02Rik,PXYLT2,SOS,XT-II,XT2,xylT-II,XYLT2 |
| Uniprot Accession | Q9H1B5,Q9EPI0,Q5QQ50,Q5QQ49 |
| Uniprot Entry Name | XYLT2_HUMAN,XYLT2_RAT,XYLT2_CANLF,XYLT2_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000015532 |
| Target Classification | N/A |
The target: XYLT2, gene name: XYLT2, also named as PXYLT2, SOS, XT-II, XT2, xylT-II. The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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