Anti-ATS2/ ADAMTS2/ ADAM-TS2 functional antibody

Anti-ATS2/ ADAMTS2/ ADAM-TS2 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to ADAMTS2/ADAMTS2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0569-Ab-1/ GM-Tg-hg-SE0569-Ab-2Anti-Human ADAMTS2 monoclonal antibodyHuman
GM-Tg-rg-SE0569-Ab-1/ GM-Tg-rg-SE0569-Ab-2Anti-Rat ADAMTS2 monoclonal antibodyRat
GM-Tg-mg-SE0569-Ab-1/ GM-Tg-mg-SE0569-Ab-2Anti-Mouse ADAMTS2 monoclonal antibodyMouse
GM-Tg-cynog-SE0569-Ab-1/ GM-Tg-cynog-SE0569-Ab-2Anti-Cynomolgus/ Rhesus macaque ADAMTS2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0569-Ab-1/ GM-Tg-felg-SE0569-Ab-2Anti-Feline ADAMTS2 monoclonal antibodyFeline
GM-Tg-cang-SE0569-Ab-1/ GM-Tg-cang-SE0569-Ab-2Anti-Canine ADAMTS2 monoclonal antibodyCanine
GM-Tg-bovg-SE0569-Ab-1/ GM-Tg-bovg-SE0569-Ab-2Anti-Bovine ADAMTS2 monoclonal antibodyBovine
GM-Tg-equg-SE0569-Ab-1/ GM-Tg-equg-SE0569-Ab-2Anti-Equine ADAMTS2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0569-Ab-1/ GM-Tg-hg-SE0569-Ab-2; GM-Tg-rg-SE0569-Ab-1/ GM-Tg-rg-SE0569-Ab-2;
GM-Tg-mg-SE0569-Ab-1/ GM-Tg-mg-SE0569-Ab-2; GM-Tg-cynog-SE0569-Ab-1/ GM-Tg-cynog-SE0569-Ab-2;
GM-Tg-felg-SE0569-Ab-1/ GM-Tg-felg-SE0569-Ab-2; GM-Tg-cang-SE0569-Ab-1/ GM-Tg-cang-SE0569-Ab-2;
GM-Tg-bovg-SE0569-Ab-1/ GM-Tg-bovg-SE0569-Ab-2; GM-Tg-equg-SE0569-Ab-1/ GM-Tg-equg-SE0569-Ab-2
Products NameAnti-ADAMTS2 monoclonal antibody
Formatmab
Target NameADAMTS2
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ADAMTS2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0569-Ag-1Recombinant multi-species ATS2/ ADAMTS2/ ADAM-TS2 protein
    ORF Viral VectorpGMAD000269human ADAMTS2 Adenovirus plasmid
    ORF Viral VectorvGMAD000269human ADAMTS2 Adenovirus particle


    Target information

    Target IDGM-SE0569
    Target NameADAMTS2
    Gene ID9509,216725,287899,713532,481453,101096945,282401,100630632
    Gene Symbol and SynonymsADAM-TS 2,ADAM-TS2,ADAMTS-2,ADAMTS-3,ADAMTS2,EDSDERMS,NPI,PC I-NP,PCI-NP,PCINP,PCPNI,PNPI,RGD1565950
    Uniprot AccessionO95450,P79331
    Uniprot Entry NameATS2_HUMAN,ATS2_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000087116
    Target ClassificationN/A

    The target: ADAMTS2, gene name: ADAMTS2, also named as ADAM-TS2, ADAMTS-2, ADAMTS-3, EDSDERMS, NPI, PC I-NP, PCI-NP, PCINP, PCPNI, PNPI. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature procollagen N-proteinase. This proteinase excises the N-propeptide of the fibrillar procollagens types I-III and type V. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.