- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-AFG1L/ AFG1/ LACE1 functional antibody
Anti-AFG1L/ AFG1/ LACE1 functional antibody for cell culture, ELISA & in-vivo assay
Go to AFG1L/AFG1L products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0570-Ab-1/ GM-Tg-hg-SE0570-Ab-2 | Anti-Human AFG1L monoclonal antibody | Human |
| GM-Tg-rg-SE0570-Ab-1/ GM-Tg-rg-SE0570-Ab-2 | Anti-Rat AFG1L monoclonal antibody | Rat |
| GM-Tg-mg-SE0570-Ab-1/ GM-Tg-mg-SE0570-Ab-2 | Anti-Mouse AFG1L monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0570-Ab-1/ GM-Tg-cynog-SE0570-Ab-2 | Anti-Cynomolgus/ Rhesus macaque AFG1L monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0570-Ab-1/ GM-Tg-felg-SE0570-Ab-2 | Anti-Feline AFG1L monoclonal antibody | Feline |
| GM-Tg-cang-SE0570-Ab-1/ GM-Tg-cang-SE0570-Ab-2 | Anti-Canine AFG1L monoclonal antibody | Canine |
| GM-Tg-bovg-SE0570-Ab-1/ GM-Tg-bovg-SE0570-Ab-2 | Anti-Bovine AFG1L monoclonal antibody | Bovine |
| GM-Tg-equg-SE0570-Ab-1/ GM-Tg-equg-SE0570-Ab-2 | Anti-Equine AFG1L monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0570-Ab-1/ GM-Tg-hg-SE0570-Ab-2; GM-Tg-rg-SE0570-Ab-1/ GM-Tg-rg-SE0570-Ab-2; GM-Tg-mg-SE0570-Ab-1/ GM-Tg-mg-SE0570-Ab-2; GM-Tg-cynog-SE0570-Ab-1/ GM-Tg-cynog-SE0570-Ab-2; GM-Tg-felg-SE0570-Ab-1/ GM-Tg-felg-SE0570-Ab-2; GM-Tg-cang-SE0570-Ab-1/ GM-Tg-cang-SE0570-Ab-2; GM-Tg-bovg-SE0570-Ab-1/ GM-Tg-bovg-SE0570-Ab-2; GM-Tg-equg-SE0570-Ab-1/ GM-Tg-equg-SE0570-Ab-2 |
| Products Name | Anti-AFG1L monoclonal antibody |
| Format | mab |
| Target Name | AFG1L |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-AFG1L benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0570-Ag-1 | Recombinant multi-species AFG1L/ AFG1/ LACE1 protein |
Target information
| Target ID | GM-SE0570 |
| Target Name | AFG1L |
| Gene ID | 246269,215951,502479,700861,481952,101098634,537689,100066538 |
| Gene Symbol and Synonyms | AFG1,AFG1L,c222389,CG8520,LACE1 |
| Uniprot Accession | Q8WV93,Q32PX9 |
| Uniprot Entry Name | AFG1L_HUMAN,AFG1L_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000135537 |
| Target Classification | N/A |
The target: AFG1L, gene name: AFG1L, also named as AFG1, LACE1, c222389. This gene encodes a mitochondrial integral membrane protein that plays a role in mitochondrial protein homeostasis. The protein contains a P-loop motif and a five-domain structure that is conserved in fly, yeast, and bacteria. It functions to mediate the degradation of nuclear-encoded complex IV subunits. Two conserved estrogen receptor binding sites are located within 2.5 kb of this gene. Polymorphisms in this gene have been associated with bipolar disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
