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Anti-CALL5/ CALML5/ CLSP functional antibody
Anti-CALL5/ CALML5/ CLSP functional antibody for cell culture, ELISA & in-vivo assay
Go to CALML5/CALML5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0577-Ab-1/ GM-Tg-hg-SE0577-Ab-2 | Anti-Human CALML5 monoclonal antibody | Human |
| GM-Tg-rg-SE0577-Ab-1/ GM-Tg-rg-SE0577-Ab-2 | Anti-Rat CALML5 monoclonal antibody | Rat |
| GM-Tg-mg-SE0577-Ab-1/ GM-Tg-mg-SE0577-Ab-2 | Anti-Mouse CALML5 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0577-Ab-1/ GM-Tg-cynog-SE0577-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CALML5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0577-Ab-1/ GM-Tg-felg-SE0577-Ab-2 | Anti-Feline CALML5 monoclonal antibody | Feline |
| GM-Tg-cang-SE0577-Ab-1/ GM-Tg-cang-SE0577-Ab-2 | Anti-Canine CALML5 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0577-Ab-1/ GM-Tg-bovg-SE0577-Ab-2 | Anti-Bovine CALML5 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0577-Ab-1/ GM-Tg-equg-SE0577-Ab-2 | Anti-Equine CALML5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0577-Ab-1/ GM-Tg-hg-SE0577-Ab-2; GM-Tg-rg-SE0577-Ab-1/ GM-Tg-rg-SE0577-Ab-2; GM-Tg-mg-SE0577-Ab-1/ GM-Tg-mg-SE0577-Ab-2; GM-Tg-cynog-SE0577-Ab-1/ GM-Tg-cynog-SE0577-Ab-2; GM-Tg-felg-SE0577-Ab-1/ GM-Tg-felg-SE0577-Ab-2; GM-Tg-cang-SE0577-Ab-1/ GM-Tg-cang-SE0577-Ab-2; GM-Tg-bovg-SE0577-Ab-1/ GM-Tg-bovg-SE0577-Ab-2; GM-Tg-equg-SE0577-Ab-1/ GM-Tg-equg-SE0577-Ab-2 |
| Products Name | Anti-CALML5 monoclonal antibody |
| Format | mab |
| Target Name | CALML5 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CALML5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0577-Ag-1 | Recombinant multi-species CALL5/ CALML5/ CLSP protein |
| ORF Viral Vector | pGMLPm004816 | mouse Calm4 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004816 | mouse Calm4 Lentivirus particle |
Target information
| Target ID | GM-SE0577 |
| Target Name | CALML5 |
| Gene ID | 51806,364774,712159,100057133 |
| Gene Symbol and Synonyms | Calm4,CALML5,CLSP |
| Uniprot Accession | Q9NZT1 |
| Uniprot Entry Name | CALL5_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000178372 |
| Target Classification | N/A |
The target: CALML5, gene name: CALML5, also named as CLSP. This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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