Anti-P3H3/ GRCB/ HSU47926 functional antibody

Anti-P3H3/ GRCB/ HSU47926 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to P3H3/P3H3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0597-Ab-1/ GM-Tg-hg-SE0597-Ab-2Anti-Human P3H3 monoclonal antibodyHuman
GM-Tg-rg-SE0597-Ab-1/ GM-Tg-rg-SE0597-Ab-2Anti-Rat P3H3 monoclonal antibodyRat
GM-Tg-mg-SE0597-Ab-1/ GM-Tg-mg-SE0597-Ab-2Anti-Mouse P3H3 monoclonal antibodyMouse
GM-Tg-cynog-SE0597-Ab-1/ GM-Tg-cynog-SE0597-Ab-2Anti-Cynomolgus/ Rhesus macaque P3H3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0597-Ab-1/ GM-Tg-felg-SE0597-Ab-2Anti-Feline P3H3 monoclonal antibodyFeline
GM-Tg-cang-SE0597-Ab-1/ GM-Tg-cang-SE0597-Ab-2Anti-Canine P3H3 monoclonal antibodyCanine
GM-Tg-bovg-SE0597-Ab-1/ GM-Tg-bovg-SE0597-Ab-2Anti-Bovine P3H3 monoclonal antibodyBovine
GM-Tg-equg-SE0597-Ab-1/ GM-Tg-equg-SE0597-Ab-2Anti-Equine P3H3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0597-Ab-1/ GM-Tg-hg-SE0597-Ab-2; GM-Tg-rg-SE0597-Ab-1/ GM-Tg-rg-SE0597-Ab-2;
GM-Tg-mg-SE0597-Ab-1/ GM-Tg-mg-SE0597-Ab-2; GM-Tg-cynog-SE0597-Ab-1/ GM-Tg-cynog-SE0597-Ab-2;
GM-Tg-felg-SE0597-Ab-1/ GM-Tg-felg-SE0597-Ab-2; GM-Tg-cang-SE0597-Ab-1/ GM-Tg-cang-SE0597-Ab-2;
GM-Tg-bovg-SE0597-Ab-1/ GM-Tg-bovg-SE0597-Ab-2; GM-Tg-equg-SE0597-Ab-1/ GM-Tg-equg-SE0597-Ab-2
Products NameAnti-P3H3 monoclonal antibody
Formatmab
Target NameP3H3
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-P3H3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0597-Ag-1Recombinant multi-species P3H3/ GRCB/ HSU47926 protein


    Target information

    Target IDGM-SE0597
    Target NameP3H3
    Gene ID10536,14789,297595,713865,100686626,101093365,100060032
    Gene Symbol and SynonymsGRCB,HSU47926,LEPREL2,P3H3
    Uniprot AccessionQ8IVL6
    Uniprot Entry NameP3H3_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000110811
    Target ClassificationN/A

    The target: P3H3, gene name: P3H3, also named as GRCB, HSU47926, LEPREL2. The protein encoded by this gene belongs to the leprecan family of proteoglycans, which function as collagen prolyl hydroxylases that are required for proper collagen biosynthesis, folding and assembly. This protein, like other family members, is thought to reside in the endoplasmic reticulum. Epigenetic inactivation of this gene is associated with breast and other cancers, suggesting that it may function as a tumor suppressor. [provided by RefSeq, Aug 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.