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Anti-IGLL1/14.1/ AGM2 functional antibody
Anti-IGLL1/14.1/ AGM2 functional antibody for cell culture, ELISA & in-vivo assay
Go to IGLL1/IGLL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0620-Ab-1/ GM-Tg-hg-SE0620-Ab-2 | Anti-Human IGLL1 monoclonal antibody | Human |
| GM-Tg-rg-SE0620-Ab-1/ GM-Tg-rg-SE0620-Ab-2 | Anti-Rat IGLL1 monoclonal antibody | Rat |
| GM-Tg-mg-SE0620-Ab-1/ GM-Tg-mg-SE0620-Ab-2 | Anti-Mouse IGLL1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0620-Ab-1/ GM-Tg-cynog-SE0620-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IGLL1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0620-Ab-1/ GM-Tg-felg-SE0620-Ab-2 | Anti-Feline IGLL1 monoclonal antibody | Feline |
| GM-Tg-cang-SE0620-Ab-1/ GM-Tg-cang-SE0620-Ab-2 | Anti-Canine IGLL1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0620-Ab-1/ GM-Tg-bovg-SE0620-Ab-2 | Anti-Bovine IGLL1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0620-Ab-1/ GM-Tg-equg-SE0620-Ab-2 | Anti-Equine IGLL1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0620-Ab-1/ GM-Tg-hg-SE0620-Ab-2; GM-Tg-rg-SE0620-Ab-1/ GM-Tg-rg-SE0620-Ab-2; GM-Tg-mg-SE0620-Ab-1/ GM-Tg-mg-SE0620-Ab-2; GM-Tg-cynog-SE0620-Ab-1/ GM-Tg-cynog-SE0620-Ab-2; GM-Tg-felg-SE0620-Ab-1/ GM-Tg-felg-SE0620-Ab-2; GM-Tg-cang-SE0620-Ab-1/ GM-Tg-cang-SE0620-Ab-2; GM-Tg-bovg-SE0620-Ab-1/ GM-Tg-bovg-SE0620-Ab-2; GM-Tg-equg-SE0620-Ab-1/ GM-Tg-equg-SE0620-Ab-2 |
| Products Name | Anti-IGLL1 monoclonal antibody |
| Format | mab |
| Target Name | IGLL1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IGLL1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0620-Ag-1 | Recombinant multi-species IGLL1/14.1/ AGM2 protein |
Target information
| Target ID | GM-SE0620 |
| Target Name | IGLL1 |
| Gene ID | 3543,107000597,407114 |
| Gene Symbol and Synonyms | 14.1,AGM2,CD179b,IGL1,IGL5,IGLJ14.1,IGLL,IGLL1,IGO,IGVPB,VPREB2 |
| Uniprot Accession | P15814 |
| Uniprot Entry Name | IGLL1_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000128322 |
| Target Classification | N/A |
The target: IGLL1, gene name: IGLL1, also named as 14.1, AGM2, CD179b, IGL1, IGL5, IGLJ14.1, IGLL, IGO, IGVPB, VPREB2. The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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