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Anti-PGCA/ ACAN/ AGC1 functional antibody
Anti-PGCA/ ACAN/ AGC1 functional antibody for cell culture, ELISA & in-vivo assay
Go to ACAN/ACAN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0633-Ab-1/ GM-Tg-hg-SE0633-Ab-2 | Anti-Human ACAN monoclonal antibody | Human |
| GM-Tg-rg-SE0633-Ab-1/ GM-Tg-rg-SE0633-Ab-2 | Anti-Rat ACAN monoclonal antibody | Rat |
| GM-Tg-mg-SE0633-Ab-1/ GM-Tg-mg-SE0633-Ab-2 | Anti-Mouse ACAN monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0633-Ab-1/ GM-Tg-cynog-SE0633-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ACAN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0633-Ab-1/ GM-Tg-felg-SE0633-Ab-2 | Anti-Feline ACAN monoclonal antibody | Feline |
| GM-Tg-cang-SE0633-Ab-1/ GM-Tg-cang-SE0633-Ab-2 | Anti-Canine ACAN monoclonal antibody | Canine |
| GM-Tg-bovg-SE0633-Ab-1/ GM-Tg-bovg-SE0633-Ab-2 | Anti-Bovine ACAN monoclonal antibody | Bovine |
| GM-Tg-equg-SE0633-Ab-1/ GM-Tg-equg-SE0633-Ab-2 | Anti-Equine ACAN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0633-Ab-1/ GM-Tg-hg-SE0633-Ab-2; GM-Tg-rg-SE0633-Ab-1/ GM-Tg-rg-SE0633-Ab-2; GM-Tg-mg-SE0633-Ab-1/ GM-Tg-mg-SE0633-Ab-2; GM-Tg-cynog-SE0633-Ab-1/ GM-Tg-cynog-SE0633-Ab-2; GM-Tg-felg-SE0633-Ab-1/ GM-Tg-felg-SE0633-Ab-2; GM-Tg-cang-SE0633-Ab-1/ GM-Tg-cang-SE0633-Ab-2; GM-Tg-bovg-SE0633-Ab-1/ GM-Tg-bovg-SE0633-Ab-2; GM-Tg-equg-SE0633-Ab-1/ GM-Tg-equg-SE0633-Ab-2 |
| Products Name | Anti-ACAN monoclonal antibody |
| Format | mab |
| Target Name | ACAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ACAN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0633-Ag-1 | Recombinant multi-species PGCA/ ACAN/ AGC1 protein |
Target information
| Target ID | GM-SE0633 |
| Target Name | ACAN |
| Gene ID | 176,11595,58968,698498,403828,101084542,280985,100033876 |
| Gene Symbol and Synonyms | ACAN,Agc,AGC1,AGCAN,b2b183Clo,cmd,CSPCP,CSPG1,CSPGCP,MSK16,SEDK,SSOAOD |
| Uniprot Accession | P16112,P07897,Q28343,P13608 |
| Uniprot Entry Name | PGCA_HUMAN,PGCA_RAT,PGCA_CANLF,PGCA_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000157766 |
| Target Classification | N/A |
The target: ACAN, gene name: ACAN, also named as AGC1, AGCAN, CSPG1, CSPGCP, MSK16, SEDK, SSOAOD. This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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