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Anti-ATS8/ ADAMTS8/ ADAM-TS8 functional antibody
Anti-ATS8/ ADAMTS8/ ADAM-TS8 functional antibody for cell culture, ELISA & in-vivo assay
Go to ADAMTS8/ADAMTS8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0649-Ab-1/ GM-Tg-hg-SE0649-Ab-2 | Anti-Human ADAMTS8 monoclonal antibody | Human |
| GM-Tg-rg-SE0649-Ab-1/ GM-Tg-rg-SE0649-Ab-2 | Anti-Rat ADAMTS8 monoclonal antibody | Rat |
| GM-Tg-mg-SE0649-Ab-1/ GM-Tg-mg-SE0649-Ab-2 | Anti-Mouse ADAMTS8 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0649-Ab-1/ GM-Tg-cynog-SE0649-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ADAMTS8 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0649-Ab-1/ GM-Tg-felg-SE0649-Ab-2 | Anti-Feline ADAMTS8 monoclonal antibody | Feline |
| GM-Tg-cang-SE0649-Ab-1/ GM-Tg-cang-SE0649-Ab-2 | Anti-Canine ADAMTS8 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0649-Ab-1/ GM-Tg-bovg-SE0649-Ab-2 | Anti-Bovine ADAMTS8 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0649-Ab-1/ GM-Tg-equg-SE0649-Ab-2 | Anti-Equine ADAMTS8 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0649-Ab-1/ GM-Tg-hg-SE0649-Ab-2; GM-Tg-rg-SE0649-Ab-1/ GM-Tg-rg-SE0649-Ab-2; GM-Tg-mg-SE0649-Ab-1/ GM-Tg-mg-SE0649-Ab-2; GM-Tg-cynog-SE0649-Ab-1/ GM-Tg-cynog-SE0649-Ab-2; GM-Tg-felg-SE0649-Ab-1/ GM-Tg-felg-SE0649-Ab-2; GM-Tg-cang-SE0649-Ab-1/ GM-Tg-cang-SE0649-Ab-2; GM-Tg-bovg-SE0649-Ab-1/ GM-Tg-bovg-SE0649-Ab-2; GM-Tg-equg-SE0649-Ab-1/ GM-Tg-equg-SE0649-Ab-2 |
| Products Name | Anti-ADAMTS8 monoclonal antibody |
| Format | mab |
| Target Name | ADAMTS8 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ADAMTS8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0649-Ag-1 | Recombinant multi-species ATS8/ ADAMTS8/ ADAM-TS8 protein |
Target information
| Target ID | GM-SE0649 |
| Target Name | ADAMTS8 |
| Gene ID | 11095,30806,300475,718962,100684302,101096009,512544,100072682 |
| Gene Symbol and Synonyms | ADAM-TS8,ADAMTS8,METH-2,METH2 |
| Uniprot Accession | Q9UP79 |
| Uniprot Entry Name | ATS8_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000134917 |
| Target Classification | N/A |
The target: ADAMTS8, gene name: ADAMTS8, also named as ADAM-TS8, METH2. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. Reduced expression of this gene has been observed in multiple human cancers and this gene has been proposed as a potential tumor suppressor. [provided by RefSeq, Feb 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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