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Anti-MIS/ AMH/ MIF functional antibody
Anti-MIS/ AMH/ MIF functional antibody for cell culture, ELISA & in-vivo assay
Go to AMH/AMH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0660-Ab-1/ GM-Tg-hg-SE0660-Ab-2 | Anti-Human AMH monoclonal antibody | Human |
| GM-Tg-rg-SE0660-Ab-1/ GM-Tg-rg-SE0660-Ab-2 | Anti-Rat AMH monoclonal antibody | Rat |
| GM-Tg-mg-SE0660-Ab-1/ GM-Tg-mg-SE0660-Ab-2 | Anti-Mouse AMH monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0660-Ab-1/ GM-Tg-cynog-SE0660-Ab-2 | Anti-Cynomolgus/ Rhesus macaque AMH monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0660-Ab-1/ GM-Tg-felg-SE0660-Ab-2 | Anti-Feline AMH monoclonal antibody | Feline |
| GM-Tg-cang-SE0660-Ab-1/ GM-Tg-cang-SE0660-Ab-2 | Anti-Canine AMH monoclonal antibody | Canine |
| GM-Tg-bovg-SE0660-Ab-1/ GM-Tg-bovg-SE0660-Ab-2 | Anti-Bovine AMH monoclonal antibody | Bovine |
| GM-Tg-equg-SE0660-Ab-1/ GM-Tg-equg-SE0660-Ab-2 | Anti-Equine AMH monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0660-Ab-1/ GM-Tg-hg-SE0660-Ab-2; GM-Tg-rg-SE0660-Ab-1/ GM-Tg-rg-SE0660-Ab-2; GM-Tg-mg-SE0660-Ab-1/ GM-Tg-mg-SE0660-Ab-2; GM-Tg-cynog-SE0660-Ab-1/ GM-Tg-cynog-SE0660-Ab-2; GM-Tg-felg-SE0660-Ab-1/ GM-Tg-felg-SE0660-Ab-2; GM-Tg-cang-SE0660-Ab-1/ GM-Tg-cang-SE0660-Ab-2; GM-Tg-bovg-SE0660-Ab-1/ GM-Tg-bovg-SE0660-Ab-2; GM-Tg-equg-SE0660-Ab-1/ GM-Tg-equg-SE0660-Ab-2 |
| Products Name | Anti-AMH monoclonal antibody |
| Format | mab |
| Target Name | AMH |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Diagnostic target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-AMH benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0660-Ag-1 | Recombinant multi-species MIS/ AMH/ MIF protein |
| ORF Viral Vector | pGMLV000170 | mouse Amh Lentivirus plasmid |
| ORF Viral Vector | vGMLV000170 | mouse Amh Lentivirus particle |
Target information
| Target ID | GM-SE0660 |
| Target Name | AMH |
| Gene ID | 268,11705,25378,717539,485072,101080263,280718,102148318 |
| Gene Symbol and Synonyms | AMH,MIF,MIS |
| Uniprot Accession | P03971,P49000,P03972 |
| Uniprot Entry Name | MIS_HUMAN,MIS_RAT,MIS_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Diagnostics Biomarker |
| Disease | Hodgkin's lymphoma |
| Gene Ensembl | ENSG00000104899 |
| Target Classification | N/A |
The target: AMH, gene name: AMH, also named as MIF, MIS. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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