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Anti-BMPER/ CRIM3/ CV-2 functional antibody
Anti-BMPER/ CRIM3/ CV-2 functional antibody for cell culture, ELISA & in-vivo assay
Go to BMPER/BMPER products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0689-Ab-1/ GM-Tg-hg-SE0689-Ab-2 | Anti-Human BMPER monoclonal antibody | Human |
| GM-Tg-rg-SE0689-Ab-1/ GM-Tg-rg-SE0689-Ab-2 | Anti-Rat BMPER monoclonal antibody | Rat |
| GM-Tg-mg-SE0689-Ab-1/ GM-Tg-mg-SE0689-Ab-2 | Anti-Mouse BMPER monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0689-Ab-1/ GM-Tg-cynog-SE0689-Ab-2 | Anti-Cynomolgus/ Rhesus macaque BMPER monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0689-Ab-1/ GM-Tg-felg-SE0689-Ab-2 | Anti-Feline BMPER monoclonal antibody | Feline |
| GM-Tg-cang-SE0689-Ab-1/ GM-Tg-cang-SE0689-Ab-2 | Anti-Canine BMPER monoclonal antibody | Canine |
| GM-Tg-bovg-SE0689-Ab-1/ GM-Tg-bovg-SE0689-Ab-2 | Anti-Bovine BMPER monoclonal antibody | Bovine |
| GM-Tg-equg-SE0689-Ab-1/ GM-Tg-equg-SE0689-Ab-2 | Anti-Equine BMPER monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0689-Ab-1/ GM-Tg-hg-SE0689-Ab-2; GM-Tg-rg-SE0689-Ab-1/ GM-Tg-rg-SE0689-Ab-2; GM-Tg-mg-SE0689-Ab-1/ GM-Tg-mg-SE0689-Ab-2; GM-Tg-cynog-SE0689-Ab-1/ GM-Tg-cynog-SE0689-Ab-2; GM-Tg-felg-SE0689-Ab-1/ GM-Tg-felg-SE0689-Ab-2; GM-Tg-cang-SE0689-Ab-1/ GM-Tg-cang-SE0689-Ab-2; GM-Tg-bovg-SE0689-Ab-1/ GM-Tg-bovg-SE0689-Ab-2; GM-Tg-equg-SE0689-Ab-1/ GM-Tg-equg-SE0689-Ab-2 |
| Products Name | Anti-BMPER monoclonal antibody |
| Format | mab |
| Target Name | BMPER |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-BMPER benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0689-Ag-1 | Recombinant multi-species BMPER/ CRIM3/ CV-2 protein |
| ORF Viral Vector | vGMLP001459 | human BMPER Lentivirus particle |
| ORF Viral Vector | pGMLP001459 | human BMPER Lentivirus plasmid |
Target information
| Target ID | GM-SE0689 |
| Target Name | BMPER |
| Gene ID | 168667,73230,300455,708120,475280,101092594,534101,100070275 |
| Gene Symbol and Synonyms | 3110056H04Rik,BMPER,CRIM3,CV-2,CV2,RGD1563373 |
| Uniprot Accession | Q8N8U9 |
| Uniprot Entry Name | BMPER_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000164619 |
| Target Classification | N/A |
The target: BMPER, gene name: BMPER, also named as CRIM3, CV-2, CV2. This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis. [provided by RefSeq, Dec 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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