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Anti-EST4A/ CES4A/ CES6 functional antibody
Anti-EST4A/ CES4A/ CES6 functional antibody for cell culture, ELISA & in-vivo assay
Go to CES4A/CES4A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0760-Ab-1/ GM-Tg-hg-SE0760-Ab-2 | Anti-Human CES4A monoclonal antibody | Human |
| GM-Tg-rg-SE0760-Ab-1/ GM-Tg-rg-SE0760-Ab-2 | Anti-Rat CES4A monoclonal antibody | Rat |
| GM-Tg-mg-SE0760-Ab-1/ GM-Tg-mg-SE0760-Ab-2 | Anti-Mouse CES4A monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0760-Ab-1/ GM-Tg-cynog-SE0760-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CES4A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0760-Ab-1/ GM-Tg-felg-SE0760-Ab-2 | Anti-Feline CES4A monoclonal antibody | Feline |
| GM-Tg-cang-SE0760-Ab-1/ GM-Tg-cang-SE0760-Ab-2 | Anti-Canine CES4A monoclonal antibody | Canine |
| GM-Tg-bovg-SE0760-Ab-1/ GM-Tg-bovg-SE0760-Ab-2 | Anti-Bovine CES4A monoclonal antibody | Bovine |
| GM-Tg-equg-SE0760-Ab-1/ GM-Tg-equg-SE0760-Ab-2 | Anti-Equine CES4A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0760-Ab-1/ GM-Tg-hg-SE0760-Ab-2; GM-Tg-rg-SE0760-Ab-1/ GM-Tg-rg-SE0760-Ab-2; GM-Tg-mg-SE0760-Ab-1/ GM-Tg-mg-SE0760-Ab-2; GM-Tg-cynog-SE0760-Ab-1/ GM-Tg-cynog-SE0760-Ab-2; GM-Tg-felg-SE0760-Ab-1/ GM-Tg-felg-SE0760-Ab-2; GM-Tg-cang-SE0760-Ab-1/ GM-Tg-cang-SE0760-Ab-2; GM-Tg-bovg-SE0760-Ab-1/ GM-Tg-bovg-SE0760-Ab-2; GM-Tg-equg-SE0760-Ab-1/ GM-Tg-equg-SE0760-Ab-2 |
| Products Name | Anti-CES4A monoclonal antibody |
| Format | mab |
| Target Name | CES4A |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CES4A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0760-Ag-1 | Recombinant multi-species EST4A/ CES4A/ CES6 protein |
Target information
| Target ID | GM-SE0760 |
| Target Name | CES4A |
| Gene ID | 283848,234677,291955,697791,101087285,529706 |
| Gene Symbol and Synonyms | CES4A,CES6,CES8,RGD1307418 |
| Uniprot Accession | Q5XG92,P0C6R3 |
| Uniprot Entry Name | EST4A_HUMAN,EST4A_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000172824 |
| Target Classification | N/A |
The target: CES4A, gene name: CES4A, also named as CES6, CES8. This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES6, encodes a secreted enzyme, and may play a role in the detoxification of drugs and xenobiotics in neural and other tissues of the body and in the cerebrospinal fluid. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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