Anti-CH3L2/ CHI3L2/ CHIL2 functional antibody

Anti-CH3L2/ CHI3L2/ CHIL2 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to CHI3L2/CHI3L2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0776-Ab-1/ GM-Tg-hg-SE0776-Ab-2Anti-Human CHI3L2 monoclonal antibodyHuman
GM-Tg-rg-SE0776-Ab-1/ GM-Tg-rg-SE0776-Ab-2Anti-Rat CHI3L2 monoclonal antibodyRat
GM-Tg-mg-SE0776-Ab-1/ GM-Tg-mg-SE0776-Ab-2Anti-Mouse CHI3L2 monoclonal antibodyMouse
GM-Tg-cynog-SE0776-Ab-1/ GM-Tg-cynog-SE0776-Ab-2Anti-Cynomolgus/ Rhesus macaque CHI3L2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0776-Ab-1/ GM-Tg-felg-SE0776-Ab-2Anti-Feline CHI3L2 monoclonal antibodyFeline
GM-Tg-cang-SE0776-Ab-1/ GM-Tg-cang-SE0776-Ab-2Anti-Canine CHI3L2 monoclonal antibodyCanine
GM-Tg-bovg-SE0776-Ab-1/ GM-Tg-bovg-SE0776-Ab-2Anti-Bovine CHI3L2 monoclonal antibodyBovine
GM-Tg-equg-SE0776-Ab-1/ GM-Tg-equg-SE0776-Ab-2Anti-Equine CHI3L2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0776-Ab-1/ GM-Tg-hg-SE0776-Ab-2; GM-Tg-rg-SE0776-Ab-1/ GM-Tg-rg-SE0776-Ab-2;
GM-Tg-mg-SE0776-Ab-1/ GM-Tg-mg-SE0776-Ab-2; GM-Tg-cynog-SE0776-Ab-1/ GM-Tg-cynog-SE0776-Ab-2;
GM-Tg-felg-SE0776-Ab-1/ GM-Tg-felg-SE0776-Ab-2; GM-Tg-cang-SE0776-Ab-1/ GM-Tg-cang-SE0776-Ab-2;
GM-Tg-bovg-SE0776-Ab-1/ GM-Tg-bovg-SE0776-Ab-2; GM-Tg-equg-SE0776-Ab-1/ GM-Tg-equg-SE0776-Ab-2
Products NameAnti-CHI3L2 monoclonal antibody
Formatmab
Target NameCHI3L2
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CHI3L2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0776-Ag-1Recombinant multi-species CH3L2/ CHI3L2/ CHIL2 protein


    Target information

    Target IDGM-SE0776
    Target NameCHI3L2
    Gene ID1117,705024,513513,102147633
    Gene Symbol and SynonymsCHI3L2,CHIL2,YKL-39,YKL39
    Uniprot AccessionQ15782
    Uniprot Entry NameCH3L2_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000064886
    Target ClassificationN/A

    The target: CHI3L2, gene name: CHI3L2, also named as CHIL2, YKL-39, YKL39. The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is secreted and is involved in cartilage biogenesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.