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Anti-CL18A/ CLEC18A/ MRCL functional antibody
Anti-CL18A/ CLEC18A/ MRCL functional antibody for cell culture, ELISA & in-vivo assay
Go to CLEC18A/CLEC18A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0782-Ab-1/ GM-Tg-hg-SE0782-Ab-2 | Anti-Human CLEC18A monoclonal antibody | Human |
| GM-Tg-rg-SE0782-Ab-1/ GM-Tg-rg-SE0782-Ab-2 | Anti-Rat CLEC18A monoclonal antibody | Rat |
| GM-Tg-mg-SE0782-Ab-1/ GM-Tg-mg-SE0782-Ab-2 | Anti-Mouse CLEC18A monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0782-Ab-1/ GM-Tg-cynog-SE0782-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CLEC18A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0782-Ab-1/ GM-Tg-felg-SE0782-Ab-2 | Anti-Feline CLEC18A monoclonal antibody | Feline |
| GM-Tg-cang-SE0782-Ab-1/ GM-Tg-cang-SE0782-Ab-2 | Anti-Canine CLEC18A monoclonal antibody | Canine |
| GM-Tg-bovg-SE0782-Ab-1/ GM-Tg-bovg-SE0782-Ab-2 | Anti-Bovine CLEC18A monoclonal antibody | Bovine |
| GM-Tg-equg-SE0782-Ab-1/ GM-Tg-equg-SE0782-Ab-2 | Anti-Equine CLEC18A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0782-Ab-1/ GM-Tg-hg-SE0782-Ab-2; GM-Tg-rg-SE0782-Ab-1/ GM-Tg-rg-SE0782-Ab-2; GM-Tg-mg-SE0782-Ab-1/ GM-Tg-mg-SE0782-Ab-2; GM-Tg-cynog-SE0782-Ab-1/ GM-Tg-cynog-SE0782-Ab-2; GM-Tg-felg-SE0782-Ab-1/ GM-Tg-felg-SE0782-Ab-2; GM-Tg-cang-SE0782-Ab-1/ GM-Tg-cang-SE0782-Ab-2; GM-Tg-bovg-SE0782-Ab-1/ GM-Tg-bovg-SE0782-Ab-2; GM-Tg-equg-SE0782-Ab-1/ GM-Tg-equg-SE0782-Ab-2 |
| Products Name | Anti-CLEC18A monoclonal antibody |
| Format | mab |
| Target Name | CLEC18A |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CLEC18A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0782-Ag-1 | Recombinant multi-species CL18A/ CLEC18A/ MRCL protein |
| ORF Viral Vector | pGMLPm005438 | mouse Clec18a Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005438 | mouse Clec18a Lentivirus particle |
Target information
| Target ID | GM-SE0782 |
| Target Name | CLEC18A |
| Gene ID | 348174 |
| Gene Symbol and Synonyms | CLEC18A,MRCL,MRCL1,MRLP2 |
| Uniprot Accession | A5D8T8 |
| Uniprot Entry Name | CL18A_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000157322 |
| Target Classification | N/A |
The target: CLEC18A, gene name: CLEC18A, also named as MRCL, MRCL1, MRLP2. This is one of three closely related paralogous genes on chromosome 16 encoding secreted proteins containing C-type lectin domains. These domains bind to carbohydrates in the presence of calcium, and may be involved in cell adhesion, immune response and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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