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Anti-COCH/ COCH-5B25B2/ DFNA9 functional antibody
Anti-COCH/ COCH-5B25B2/ DFNA9 functional antibody for cell culture, ELISA & in-vivo assay
Go to COCH/COCH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0790-Ab-1/ GM-Tg-hg-SE0790-Ab-2 | Anti-Human COCH monoclonal antibody | Human |
| GM-Tg-rg-SE0790-Ab-1/ GM-Tg-rg-SE0790-Ab-2 | Anti-Rat COCH monoclonal antibody | Rat |
| GM-Tg-mg-SE0790-Ab-1/ GM-Tg-mg-SE0790-Ab-2 | Anti-Mouse COCH monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0790-Ab-1/ GM-Tg-cynog-SE0790-Ab-2 | Anti-Cynomolgus/ Rhesus macaque COCH monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0790-Ab-1/ GM-Tg-felg-SE0790-Ab-2 | Anti-Feline COCH monoclonal antibody | Feline |
| GM-Tg-cang-SE0790-Ab-1/ GM-Tg-cang-SE0790-Ab-2 | Anti-Canine COCH monoclonal antibody | Canine |
| GM-Tg-bovg-SE0790-Ab-1/ GM-Tg-bovg-SE0790-Ab-2 | Anti-Bovine COCH monoclonal antibody | Bovine |
| GM-Tg-equg-SE0790-Ab-1/ GM-Tg-equg-SE0790-Ab-2 | Anti-Equine COCH monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0790-Ab-1/ GM-Tg-hg-SE0790-Ab-2; GM-Tg-rg-SE0790-Ab-1/ GM-Tg-rg-SE0790-Ab-2; GM-Tg-mg-SE0790-Ab-1/ GM-Tg-mg-SE0790-Ab-2; GM-Tg-cynog-SE0790-Ab-1/ GM-Tg-cynog-SE0790-Ab-2; GM-Tg-felg-SE0790-Ab-1/ GM-Tg-felg-SE0790-Ab-2; GM-Tg-cang-SE0790-Ab-1/ GM-Tg-cang-SE0790-Ab-2; GM-Tg-bovg-SE0790-Ab-1/ GM-Tg-bovg-SE0790-Ab-2; GM-Tg-equg-SE0790-Ab-1/ GM-Tg-equg-SE0790-Ab-2 |
| Products Name | Anti-COCH monoclonal antibody |
| Format | mab |
| Target Name | COCH |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-COCH benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0790-Ag-1 | Recombinant multi-species COCH/ COCH-5B25B2/ DFNA9 protein |
Target information
| Target ID | GM-SE0790 |
| Target Name | COCH |
| Gene ID | 1690,12810,362735,717114,490640,101081053,504316,100055742 |
| Gene Symbol and Synonyms | COCH,COCH-5B2,COCH5B2,D12H14S564E,DFNA9,DFNB110 |
| Uniprot Accession | O43405,Q5EA64 |
| Uniprot Entry Name | COCH_HUMAN,COCH_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000100473 |
| Target Classification | N/A |
The target: COCH, gene name: COCH, also named as COCH-5B25B2, DFNA9, DFNB110, COCH. The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq, Oct 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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