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Anti-CO4A1/ COL4A1/ BSVD functional antibody
Anti-CO4A1/ COL4A1/ BSVD functional antibody for cell culture, ELISA & in-vivo assay
Go to COL4A1/COL4A1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0799-Ab-1/ GM-Tg-hg-SE0799-Ab-2 | Anti-Human COL4A1 monoclonal antibody | Human |
| GM-Tg-rg-SE0799-Ab-1/ GM-Tg-rg-SE0799-Ab-2 | Anti-Rat COL4A1 monoclonal antibody | Rat |
| GM-Tg-mg-SE0799-Ab-1/ GM-Tg-mg-SE0799-Ab-2 | Anti-Mouse COL4A1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0799-Ab-1/ GM-Tg-cynog-SE0799-Ab-2 | Anti-Cynomolgus/ Rhesus macaque COL4A1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0799-Ab-1/ GM-Tg-felg-SE0799-Ab-2 | Anti-Feline COL4A1 monoclonal antibody | Feline |
| GM-Tg-cang-SE0799-Ab-1/ GM-Tg-cang-SE0799-Ab-2 | Anti-Canine COL4A1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0799-Ab-1/ GM-Tg-bovg-SE0799-Ab-2 | Anti-Bovine COL4A1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0799-Ab-1/ GM-Tg-equg-SE0799-Ab-2 | Anti-Equine COL4A1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0799-Ab-1/ GM-Tg-hg-SE0799-Ab-2; GM-Tg-rg-SE0799-Ab-1/ GM-Tg-rg-SE0799-Ab-2; GM-Tg-mg-SE0799-Ab-1/ GM-Tg-mg-SE0799-Ab-2; GM-Tg-cynog-SE0799-Ab-1/ GM-Tg-cynog-SE0799-Ab-2; GM-Tg-felg-SE0799-Ab-1/ GM-Tg-felg-SE0799-Ab-2; GM-Tg-cang-SE0799-Ab-1/ GM-Tg-cang-SE0799-Ab-2; GM-Tg-bovg-SE0799-Ab-1/ GM-Tg-bovg-SE0799-Ab-2; GM-Tg-equg-SE0799-Ab-1/ GM-Tg-equg-SE0799-Ab-2 |
| Products Name | Anti-COL4A1 monoclonal antibody |
| Format | mab |
| Target Name | COL4A1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-COL4A1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0799-Ag-1 | Recombinant multi-species CO4A1/ COL4A1/ BSVD protein |
Target information
| Target ID | GM-SE0799 |
| Target Name | COL4A1 |
| Gene ID | 1282,12826,290905,700281,403496,101096030,282191,100066148 |
| Gene Symbol and Synonyms | Bru,BSVD,BSVD1,Col4a-1,COL4A1,COL4A1s,PADMAL,RATOR,Raw,Svc |
| Uniprot Accession | P02462,Q7SIB2 |
| Uniprot Entry Name | CO4A1_HUMAN,CO4A1_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000187498 |
| Target Classification | N/A |
The target: COL4A1, gene name: COL4A1, also named as BSVD, RATOR. This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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