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Anti-CO4A4/ COL4A4/ CA44 functional antibody
Anti-CO4A4/ COL4A4/ CA44 functional antibody for cell culture, ELISA & in-vivo assay
Go to COL4A4/COL4A4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0801-Ab-1/ GM-Tg-hg-SE0801-Ab-2 | Anti-Human COL4A4 monoclonal antibody | Human |
| GM-Tg-rg-SE0801-Ab-1/ GM-Tg-rg-SE0801-Ab-2 | Anti-Rat COL4A4 monoclonal antibody | Rat |
| GM-Tg-mg-SE0801-Ab-1/ GM-Tg-mg-SE0801-Ab-2 | Anti-Mouse COL4A4 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0801-Ab-1/ GM-Tg-cynog-SE0801-Ab-2 | Anti-Cynomolgus/ Rhesus macaque COL4A4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0801-Ab-1/ GM-Tg-felg-SE0801-Ab-2 | Anti-Feline COL4A4 monoclonal antibody | Feline |
| GM-Tg-cang-SE0801-Ab-1/ GM-Tg-cang-SE0801-Ab-2 | Anti-Canine COL4A4 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0801-Ab-1/ GM-Tg-bovg-SE0801-Ab-2 | Anti-Bovine COL4A4 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0801-Ab-1/ GM-Tg-equg-SE0801-Ab-2 | Anti-Equine COL4A4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0801-Ab-1/ GM-Tg-hg-SE0801-Ab-2; GM-Tg-rg-SE0801-Ab-1/ GM-Tg-rg-SE0801-Ab-2; GM-Tg-mg-SE0801-Ab-1/ GM-Tg-mg-SE0801-Ab-2; GM-Tg-cynog-SE0801-Ab-1/ GM-Tg-cynog-SE0801-Ab-2; GM-Tg-felg-SE0801-Ab-1/ GM-Tg-felg-SE0801-Ab-2; GM-Tg-cang-SE0801-Ab-1/ GM-Tg-cang-SE0801-Ab-2; GM-Tg-bovg-SE0801-Ab-1/ GM-Tg-bovg-SE0801-Ab-2; GM-Tg-equg-SE0801-Ab-1/ GM-Tg-equg-SE0801-Ab-2 |
| Products Name | Anti-COL4A4 monoclonal antibody |
| Format | mab |
| Target Name | COL4A4 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-COL4A4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0801-Ag-1 | Recombinant multi-species CO4A4/ COL4A4/ CA44 protein |
Target information
| Target ID | GM-SE0801 |
| Target Name | COL4A4 |
| Gene ID | 1286,12829,708287,403841,101091469,407107,100062160 |
| Gene Symbol and Synonyms | ATS2,BFH,BFH1,CA44,COL4A4,E130010M05Rik,[a]4(IV) |
| Uniprot Accession | P53420,Q29442 |
| Uniprot Entry Name | CO4A4_HUMAN,CO4A4_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | IgA glomerulonephritis |
| Gene Ensembl | ENSG00000081052 |
| Target Classification | N/A |
The target: COL4A4, gene name: COL4A4, also named as CA44. This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. This particular collagen IV subunit, however, is only found in a subset of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Mutations in this gene are associated with type II autosomal recessive Alport syndrome (hereditary glomerulonephropathy) and with familial benign hematuria (thin basement membrane disease). Two transcripts, differing only in their transcription start sites, have been identified for this gene and, as is common for collagen genes, multiple polyadenylation sites are found in the 3' UTR. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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