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Anti-COPA/ AILJK/ HEP-COP functional antibody
Anti-COPA/ AILJK/ HEP-COP functional antibody for cell culture, ELISA & in-vivo assay
Go to COPA/COPA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0810-Ab-1/ GM-Tg-hg-SE0810-Ab-2 | Anti-Human COPA monoclonal antibody | Human |
| GM-Tg-rg-SE0810-Ab-1/ GM-Tg-rg-SE0810-Ab-2 | Anti-Rat COPA monoclonal antibody | Rat |
| GM-Tg-mg-SE0810-Ab-1/ GM-Tg-mg-SE0810-Ab-2 | Anti-Mouse COPA monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0810-Ab-1/ GM-Tg-cynog-SE0810-Ab-2 | Anti-Cynomolgus/ Rhesus macaque COPA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0810-Ab-1/ GM-Tg-felg-SE0810-Ab-2 | Anti-Feline COPA monoclonal antibody | Feline |
| GM-Tg-cang-SE0810-Ab-1/ GM-Tg-cang-SE0810-Ab-2 | Anti-Canine COPA monoclonal antibody | Canine |
| GM-Tg-bovg-SE0810-Ab-1/ GM-Tg-bovg-SE0810-Ab-2 | Anti-Bovine COPA monoclonal antibody | Bovine |
| GM-Tg-equg-SE0810-Ab-1/ GM-Tg-equg-SE0810-Ab-2 | Anti-Equine COPA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0810-Ab-1/ GM-Tg-hg-SE0810-Ab-2; GM-Tg-rg-SE0810-Ab-1/ GM-Tg-rg-SE0810-Ab-2; GM-Tg-mg-SE0810-Ab-1/ GM-Tg-mg-SE0810-Ab-2; GM-Tg-cynog-SE0810-Ab-1/ GM-Tg-cynog-SE0810-Ab-2; GM-Tg-felg-SE0810-Ab-1/ GM-Tg-felg-SE0810-Ab-2; GM-Tg-cang-SE0810-Ab-1/ GM-Tg-cang-SE0810-Ab-2; GM-Tg-bovg-SE0810-Ab-1/ GM-Tg-bovg-SE0810-Ab-2; GM-Tg-equg-SE0810-Ab-1/ GM-Tg-equg-SE0810-Ab-2 |
| Products Name | Anti-COPA monoclonal antibody |
| Format | mab |
| Target Name | COPA |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-COPA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0810-Ag-1 | Recombinant multi-species COPA/ AILJK/ HEP-COP protein |
Target information
| Target ID | GM-SE0810 |
| Target Name | COPA |
| Gene ID | 1314,12847,304978,719683,478973,101090837,100126041,100053719 |
| Gene Symbol and Synonyms | AILJK,alpha-COP,COPA,HEP-COP,HEPCOP,xenin |
| Uniprot Accession | P53621,P40765,Q27954 |
| Uniprot Entry Name | COPA_HUMAN,COPA_CANLF,COPA_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000122218 |
| Target Classification | N/A |
The target: COPA, gene name: COPA, also named as AILJK, HEP-COP. In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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