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Anti-CORT/ CST-14/ CST-17 functional antibody
Anti-CORT/ CST-14/ CST-17 functional antibody for cell culture, ELISA & in-vivo assay
Go to CORT/CORT products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0811-Ab-1/ GM-Tg-hg-SE0811-Ab-2 | Anti-Human CORT monoclonal antibody | Human |
| GM-Tg-rg-SE0811-Ab-1/ GM-Tg-rg-SE0811-Ab-2 | Anti-Rat CORT monoclonal antibody | Rat |
| GM-Tg-mg-SE0811-Ab-1/ GM-Tg-mg-SE0811-Ab-2 | Anti-Mouse CORT monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0811-Ab-1/ GM-Tg-cynog-SE0811-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CORT monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0811-Ab-1/ GM-Tg-felg-SE0811-Ab-2 | Anti-Feline CORT monoclonal antibody | Feline |
| GM-Tg-cang-SE0811-Ab-1/ GM-Tg-cang-SE0811-Ab-2 | Anti-Canine CORT monoclonal antibody | Canine |
| GM-Tg-bovg-SE0811-Ab-1/ GM-Tg-bovg-SE0811-Ab-2 | Anti-Bovine CORT monoclonal antibody | Bovine |
| GM-Tg-equg-SE0811-Ab-1/ GM-Tg-equg-SE0811-Ab-2 | Anti-Equine CORT monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0811-Ab-1/ GM-Tg-hg-SE0811-Ab-2; GM-Tg-rg-SE0811-Ab-1/ GM-Tg-rg-SE0811-Ab-2; GM-Tg-mg-SE0811-Ab-1/ GM-Tg-mg-SE0811-Ab-2; GM-Tg-cynog-SE0811-Ab-1/ GM-Tg-cynog-SE0811-Ab-2; GM-Tg-felg-SE0811-Ab-1/ GM-Tg-felg-SE0811-Ab-2; GM-Tg-cang-SE0811-Ab-1/ GM-Tg-cang-SE0811-Ab-2; GM-Tg-bovg-SE0811-Ab-1/ GM-Tg-bovg-SE0811-Ab-2; GM-Tg-equg-SE0811-Ab-1/ GM-Tg-equg-SE0811-Ab-2 |
| Products Name | Anti-CORT monoclonal antibody |
| Format | mab |
| Target Name | CORT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Diagnostic target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CORT benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0811-Ag-1 | Recombinant multi-species CORT/ CST-14/ CST-17 protein |
Target information
| Target ID | GM-SE0811 |
| Target Name | CORT |
| Gene ID | 1325,12854,114674163 |
| Gene Symbol and Synonyms | CORT,CST,CST-14,CST-17,CST-29,PCST,SST2 |
| Uniprot Accession | O00230 |
| Uniprot Entry Name | CORT_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Diagnostics Biomarker |
| Disease | N/A |
| Gene Ensembl | ENSG00000241563 |
| Target Classification | N/A |
The target: CORT, gene name: CORT, also named as CST-14, CST-17, CST-29. This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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