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Anti-CSH2/ CS-2/ CSB functional antibody
Anti-CSH2/ CS-2/ CSB functional antibody for cell culture, ELISA & in-vivo assay
Go to CSH2/CSH2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0827-Ab-1/ GM-Tg-hg-SE0827-Ab-2 | Anti-Human CSH2 monoclonal antibody | Human |
| GM-Tg-rg-SE0827-Ab-1/ GM-Tg-rg-SE0827-Ab-2 | Anti-Rat CSH2 monoclonal antibody | Rat |
| GM-Tg-mg-SE0827-Ab-1/ GM-Tg-mg-SE0827-Ab-2 | Anti-Mouse CSH2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0827-Ab-1/ GM-Tg-cynog-SE0827-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CSH2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0827-Ab-1/ GM-Tg-felg-SE0827-Ab-2 | Anti-Feline CSH2 monoclonal antibody | Feline |
| GM-Tg-cang-SE0827-Ab-1/ GM-Tg-cang-SE0827-Ab-2 | Anti-Canine CSH2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0827-Ab-1/ GM-Tg-bovg-SE0827-Ab-2 | Anti-Bovine CSH2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0827-Ab-1/ GM-Tg-equg-SE0827-Ab-2 | Anti-Equine CSH2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0827-Ab-1/ GM-Tg-hg-SE0827-Ab-2; GM-Tg-rg-SE0827-Ab-1/ GM-Tg-rg-SE0827-Ab-2; GM-Tg-mg-SE0827-Ab-1/ GM-Tg-mg-SE0827-Ab-2; GM-Tg-cynog-SE0827-Ab-1/ GM-Tg-cynog-SE0827-Ab-2; GM-Tg-felg-SE0827-Ab-1/ GM-Tg-felg-SE0827-Ab-2; GM-Tg-cang-SE0827-Ab-1/ GM-Tg-cang-SE0827-Ab-2; GM-Tg-bovg-SE0827-Ab-1/ GM-Tg-bovg-SE0827-Ab-2; GM-Tg-equg-SE0827-Ab-1/ GM-Tg-equg-SE0827-Ab-2 |
| Products Name | Anti-CSH2 monoclonal antibody |
| Format | mab |
| Target Name | CSH2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CSH2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0827-Ag-1 | Recombinant multi-species CSH2/ CS-2/ CSB protein |
| ORF Viral Vector | vGMLP002297 | human CSH2 Lentivirus particle |
| ORF Viral Vector | pGMLP002297 | human CSH2 Lentivirus plasmid |
Target information
| Target ID | GM-SE0827 |
| Target Name | CSH2 |
| Gene ID | 1443 |
| Gene Symbol and Synonyms | CS-2,CSB,CSH2,GHB1,hCS-B,PL |
| Uniprot Accession | P0DML3 |
| Uniprot Entry Name | CSH2_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000213218 |
| Target Classification | N/A |
The target: CSH2, gene name: CSH2, also named as CS-2, CSB, GHB1, PL, hCS-B. The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, while the ratio of 1 to 2 increases by term. Structural and expression differences provide avenues for developmental regulation and tissue specificity. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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